Perrin C, Astre C, Broquerie E, Saint Aubert B, Joyeux H
U.F.R. d'Odontologie Montpellier, France.
J Oral Pathol Med. 1990 Jan;19(1):13-5. doi: 10.1111/j.1600-0714.1990.tb00775.x.
A single injection of 5 mg of 7, 12-dimethylbenzanthracene (DMBA) resulted in a high incidence of lingual fibrosarcoma in 67 Wistar rats. No metastases were found. We studied the influence of age and sex on the incidence, latency of tumors, loss of weight and the spontaneous survival of animals. The method described offers an experimental model for the study of cachexia resulting from upper digestive and respiratory tract cancer.
对67只Wistar大鼠单次注射5毫克的7,12-二甲基苯并蒽（DMBA）后，舌纤维肉瘤的发生率很高。未发现转移情况。我们研究了年龄和性别对肿瘤发生率、潜伏期、体重减轻以及动物自然存活率的影响。所描述的方法为研究上消化道和呼吸道癌症导致的恶病质提供了一个实验模型。
