隐球菌性脑膜炎的联合抗真菌治疗
Combination antifungal therapy for cryptococcal meningitis.
作者信息
Tobias J S, Wrigley P F, Shaw E
出版信息
Postgrad Med J. 1976 May;52(607):305-8. doi: 10.1136/pgmj.52.607.305.
Abstract
Two patients with Hodgkin's disease and cryptococcal meningitis are described. Both patients were treated with a combination of the two antifungal agents, amphotericin B and flucytosine. Nephrotoxicity was easily reversible in both patients and clinical improvement was seen with this combination therapy. Intrathecal therapy with amphotericin B was used in both patients. The optimal treatment of this disease may prove to be a combination of oral flucytosine, with amphotericin B given by intrathecal injection as well as rapid low dose intravenous injection.
摘要
本文描述了两名患有霍奇金病和隐球菌性脑膜炎的患者。两名患者均接受了两种抗真菌药物两性霉素B和氟胞嘧啶联合治疗。两名患者的肾毒性均易于逆转，联合治疗可见临床改善。两名患者均采用了两性霉素B鞘内注射治疗。这种疾病的最佳治疗方法可能是口服氟胞嘧啶，联合鞘内注射两性霉素B以及快速低剂量静脉注射。
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本文引用的文献
1
DIAGNOSTIC AND PROGNOSTIC VALUE OF CLINICAL AND LABORATORY FINDINGS IN CRYPTOCOCCAL MENINGITIS, A FOLLOW-UP STUDY OF FORTY PATIENTS.
N Engl J Med. 1964 Jan 9;270:59-67. doi: 10.1056/NEJM196401092700201.
2
Subcutaneous reservoir and pump for sterile access to ventricular cerebrospinal fluid.
Lancet. 1963 Nov 9;2(7315):983-4. doi: 10.1016/s0140-6736(63)90681-0.
3
The improved prognosis of cryptococcal meningitis with amphotericin B therapy.
Ann Intern Med. 1963 Jan;58:66-83. doi: 10.7326/0003-4819-58-1-66.
4
Torulosis in Queensland: report of fourteen cases.
Med J Aust. 1956 Sep 8;43(10):378-82. doi: 10.5694/j.1326-5377.1956.tb56771.x.
5
Intraventricular administration of amphotericin B. Use of subcutaneous reservoir in four patients with mycotic meningitis.
JAMA. 1965 Nov 15;194(7):699-702. doi: 10.1001/jama.194.7.699.
6
Treatment of Candida sepsis and Cryptococcus meningitis with 5-fluorocytosine. A new antifungal agent.
JAMA. 1968 Oct 21;206(4):830-2.
7
5-fluorocytosine in the treatment of cryptococcal and candida mycoses.
Ann Intern Med. 1971 Apr;74(4):535-9. doi: 10.7326/0003-4819-74-4-535.
8
Cryptococcosis of the central nervous system. Epidemiological, clinical, and therapeutic features.
J Neurol Neurosurg Psychiatry. 1970 Aug;33(4):415-25. doi: 10.1136/jnnp.33.4.415.
9
Combination chemotherapy in the treatment of advanced Hodgkin's disease.
Ann Intern Med. 1970 Dec;73(6):881-95. doi: 10.7326/0003-4819-73-6-881.
10
Amphotericin B serum concentrations during therapy.
Appl Microbiol. 1970 Jun;19(6):955-9. doi: 10.1128/am.19.6.955-959.1970.
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