治疗期间两性霉素B的血清浓度。
Amphotericin B serum concentrations during therapy.
作者信息
Fields B T, Bates J H, Abernathy R S
出版信息
Appl Microbiol. 1970 Jun;19(6):955-9. doi: 10.1128/am.19.6.955-959.1970.
Abstract
Therapeutic outcome of patients being treated for systemic mycoses with amphotericin B is possibly related to the serum concentrations of this drug that are produced in these patients. Because current data are conflicting, the magnitude of these concentrations was restudied by using a bioassay which gave precise and accurate results. The highest of 155 serum concentrations was 2.01 mug/ml. Mean concentrations were 1.21, 0.62, and 0.32 mug/ml, at 1, 18, and 42 hr, respectively, after intravenous infusion of amphotericin B. This drug was detected in serum 7 weeks after completion of treatment, but it could not be detected 13 weeks after treatment. Drug levels did not appreciably decrease in serum stored for 8 to 9 months at - 10 C. Unequal serum content in assay tubes and measurement of assay turbidity by visual inspection may explain previously reported amphotericin B levels of 3.0 to 12.5 mug/ml.
摘要
用两性霉素B治疗系统性真菌病患者的治疗结果可能与这些患者体内产生的该药物血清浓度有关。由于目前的数据相互矛盾，因此通过使用能给出精确准确结果的生物测定法对这些浓度的大小进行了重新研究。155个血清浓度中最高的为2.01微克/毫升。静脉输注两性霉素B后，在1小时、18小时和42小时时的平均浓度分别为1.21微克/毫升、0.62微克/毫升和0.32微克/毫升。治疗结束7周后在血清中检测到该药物，但治疗13周后无法检测到。在-10℃下储存8至9个月的血清中药物水平没有明显下降。测定管中血清含量不均以及通过目视检查测定浊度可能解释了先前报道的3.0至12.5微克/毫升的两性霉素B水平。
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