体液免疫在小鼠抵御甲型流感病毒感染的宿主防御中的作用。
The role of humoral immunity in host defence against influenza A infection in mice.
作者信息
Virelizier J L, Oxford J S, Schild G C
出版信息
Postgrad Med J. 1976 Jun;52(608):332-7. doi: 10.1136/pgmj.52.608.332.
Abstract
The respective roles of cell-mediated immunity and humoral immunity in host defence were investigated in mice infected with influenza A/PR8 virus. Transferred immune spleen cells were shown to provide full protection only when they were actually secreting antibody. Serum antibody transferred in ‘physiological’ amounts was found to be protective in immunologically intact or in immunosuppressed animals. The specificity of the transferred antibody was shown to be critical, since antibody to internal components of the virus was inefficient while antibody to haemagglutinin, especially that to the strain-specific determinants of the haemagglutinin molecule, was highly efficient.
摘要
在感染甲型/PR8流感病毒的小鼠中，研究了细胞介导免疫和体液免疫在宿主防御中的各自作用。已证明，只有当转移的免疫脾细胞实际分泌抗体时，它们才能提供完全保护。发现以“生理”量转移的血清抗体在免疫功能正常或免疫抑制的动物中具有保护作用。转移抗体的特异性被证明至关重要，因为针对病毒内部成分的抗体效率低下，而针对血凝素的抗体，尤其是针对血凝素分子菌株特异性决定簇的抗体，效率很高。
相似文献
1
The role of humoral immunity in host defence against influenza A infection in mice.体液免疫在小鼠抵御甲型流感病毒感染的宿主防御中的作用。
Postgrad Med J. 1976 Jun;52(608):332-7. doi: 10.1136/pgmj.52.608.332.
2
Humoral and cell-mediated immune response to influenza virus. I. Experiments in mice.
Acta Microbiol Pol. 1982;31(2):185-94.
3
[Effect of regulator cells induced by the influenza virus in adoptive transfer].
Biull Eksp Biol Med. 1987 Jan;103(1):83-6.
4
[Comparison of cellular and humoral immunity to influenza virus in the guinea pig].[豚鼠对流感病毒的细胞免疫与体液免疫比较]
Pathol Microbiol (Basel). 1974;40(3):231-33.
5
Humoral and cell-mediated immune response to influenza virus. II. Experiments in ferrets.对流感病毒的体液免疫和细胞介导免疫反应。II. 雪貂实验。
Acta Microbiol Pol. 1982;31(2):195-202.
6
Immune responses to influenza virus in the mouse, and their role in control of the infection.小鼠对流感病毒的免疫反应及其在控制感染中的作用。
Br Med Bull. 1979 Jan;35(1):65-8. doi: 10.1093/oxfordjournals.bmb.a071544.
7
[Differentiated study of specific antibody populations as a possible way to increase the prognostic value of indicators of humoral immunity in influenza].
Vestn Akad Med Nauk SSSR. 1989(11):75-80.
8
[Effect of parenteral vaccination on the characteristics of experimental influenza in mice].
Tr Inst Im Pastera. 1979;52:155-60.
9
The effect of cigarette smoke on influenza virus infection: a murine model system.
Life Sci. 1976 Aug 1;19(3):409-12. doi: 10.1016/0024-3205(76)90046-1.
10
Local immunity in the pig respiratory tract. I. -- Cellular and humoral immune responses following swine influenza infection.
Ann Microbiol (Paris). 1977 Jul;128B(1):95-107.
引用本文的文献
1
Chapter 7 Orthomyxovirus infections.第7章 正黏病毒感染
Perspect Med Virol. 1985;1:255-343. doi: 10.1016/S0168-7069(08)70015-6. Epub 2008 May 29.
2
Rationale for treating human influenza infections by passive transfer of specific antibodies.通过特异性抗体的被动转移治疗人类流感感染的原理。
Influenza Other Respir Viruses. 2007 Mar;1(2):61-4. doi: 10.1111/j.1750-2659.2007.00012.x.
3
Control of mucosal virus infection by influenza nucleoprotein-specific CD8+ cytotoxic T lymphocytes.流感核蛋白特异性CD8 + 细胞毒性T淋巴细胞对黏膜病毒感染的控制
Respir Res. 2007 Jun 27;8(1):44. doi: 10.1186/1465-9921-8-44.
4
Use of licensed vaccines for active immunization of the immunocompromised host.使用经许可的疫苗对免疫功能低下宿主进行主动免疫。
Clin Microbiol Rev. 1998 Jan;11(1):1-26. doi: 10.1128/CMR.11.1.1.
5
6
Clearance of a persistent paramyxovirus infection is mediated by cellular immune responses but not by serum-neutralizing antibody.持续性副粘病毒感染的清除是由细胞免疫反应介导的，而非血清中和抗体。
J Virol. 1990 Nov;64(11):5403-11. doi: 10.1128/JVI.64.11.5403-5411.1990.
7
Structural assignment of novel and immunodominant antigenic sites in the neutralizing antibody response of CBA/Ca mice to influenza hemagglutinin.CBA/Ca小鼠对流感血凝素的中和抗体反应中新型免疫显性抗原位点的结构分析
J Exp Med. 1991 Apr 1;173(4):953-9. doi: 10.1084/jem.173.4.953.
8
Cross-protection in mice after immunization with H2N2, H3N2, and Heq2Neq2 influenza virus strains.用H2N2、H3N2和Heq2Neq2流感病毒株免疫小鼠后的交叉保护作用。
Infect Immun. 1978 Jul;21(1):96-101. doi: 10.1128/iai.21.1.96-101.1978.
9
The influenza virus: Antigenic composition and immune response.流感病毒：抗原组成与免疫反应。
Postgrad Med J. 1979 Feb;55(640):87-97. doi: 10.1136/pgmj.55.640.87.
本文引用的文献
1
INDUCTION OF PARTIAL SPECIFIC HETEROTYPIC IMMUNITY IN MICE BY A SINGLE INFECTION WITH INFLUENZA A VIRUS.通过单次感染甲型流感病毒诱导小鼠产生部分特异性异型免疫
J Bacteriol. 1965 Jan;89(1):170-4. doi: 10.1128/jb.89.1.170-174.1965.
2
STRUCTURAL STUDIES ON THE PROTEIN SUBUNITS FROM THREE STRAINS OF INFLUENZA VIRUS.三种流感病毒株蛋白质亚基的结构研究
J Mol Biol. 1964 Jul;9:109-24. doi: 10.1016/s0022-2836(64)80094-2.
3
Protective effects of specific immunity to viral neuraminidase on influenza virus infection of mice.针对病毒神经氨酸酶的特异性免疫对小鼠流感病毒感染的保护作用。
J Virol. 1968 Aug;2(8):778-86. doi: 10.1128/JVI.2.8.778-786.1968.
4
Immunity to influenza.
J Infect Dis. 1972 Oct;126(4):466-8. doi: 10.1093/infdis/126.4.466.
5
Immunity to influenza in ferrets. IV. Antibody in nasal secretions.雪貂对流感的免疫力。IV. 鼻分泌物中的抗体。
J Infect Dis. 1972 Oct;126(4):394-400. doi: 10.1093/infdis/126.4.394.
6
[Heterotypic crossed immunity, in the mouse, between human influenza viruses of types A and A 2].[小鼠中甲型和甲型2型人流感病毒之间的异型交叉免疫]
C R Acad Hebd Seances Acad Sci D. 1966 Dec 7;263(23):1913-6.
7
The effect of bursectomy and thymectomy on the course of avian influenza virus infection.法氏囊切除和胸腺切除对禽流感病毒感染病程的影响。
Cell Immunol. 1973 Nov;9(2):251-62. doi: 10.1016/0008-8749(73)90076-2.
8
Respiratory diseases in cyclophosphamide-treated mice. II. Decreased virulence of PR8 influenza virus.环磷酰胺处理小鼠的呼吸道疾病。II. PR8流感病毒毒力降低
Infect Immun. 1972 Jun;5(6):957-60. doi: 10.1128/iai.5.6.957-960.1972.
9
A quantitative, single-radial-diffusion test for immunological studies with influenza virus.一种用于流感病毒免疫学研究的定量单扩散试验。
J Gen Virol. 1972 Aug;16(2):231-6. doi: 10.1099/0022-1317-16-2-231.
10
Vaccination and protection experiments in mice with the human A-1957 and A-1968 strains, and the Equi-2 strain of influenza virus.用人A - 1957和A - 1968毒株以及马流感病毒Equi - 2毒株对小鼠进行的疫苗接种和保护实验。
Antonie Van Leeuwenhoek. 1973;39(3):461-71. doi: 10.1007/BF02578889.
Zotero 插件