Soricelli A, Cuocolo A, Varrone A, Discepolo A, Tedeschi E, Mainenti P P, Grivet-Fojaja M R, Covelli E M, Postiglione A, Salvatore M
Department of Diagnostic Imaging, University of Naples Federico II, Nuclear Medicine Center of the National Research Council, Italy.
J Nucl Med. 1998 May;39(5):802-6.
Thallium-201 is clinically used for the assessment of primary and recurrent brain tumors. The biologic properties of 201Tl that allow it to accumulate within the tumor cells render 201Tl useful in evaluating tumor malignancy, but its physical characteristics and nonroutine availability limits its use in some institutions, as compared to 99mTc-labeled compounds. The aim of this study was to assess the feasibility of using 99mTc-tetrofosmin for imaging brain tumors and to compare its uptake with that of 201Tl.
Twenty-six patients with 27 intracranial masses were studied with SPECT. In the first group of seven patients (Group A), the timing for optimal acquisition of the 99mTc-tetrofosmin scan was assessed. In the second group of 19 patients (Group B), two sequential 201Tl (74-148 MBq intravenous) and 99mTc-tetrofosmin (740-925 MBq intravenous) studies were performed 20 min after tracer injection and compared.
In Group A, no significant difference in the tumor-to-background (T/B) ratio among the 20-, 40- and 120-min postinjection studies was observed. In Group B, the quality of reconstructed images with 99mTc-tetrofosmin, judged visually, was superior to that of 201Tl in 47% of all studies and was comparable in the remaining 53%. A significant relationship between 201Tl and 99mTc-tetrofosmin T/B ratio (r = 0.75, p < 0.01) was found. The T/B ratio of 99mTc-tetrofosmin was significantly higher than that of 201Tl (23.3 +/- 21.5 compared to 6.1 +/- 2.9, p < 0.005).
Technetium-99m-tetrofosmin is a suitable radiotracer for the imaging of intracranial lesions with SPECT. Moreover, a better definition of tumor margins and a higher contrast between neoplastic and normal brain tissue can be achieved.
铊-201在临床上用于评估原发性和复发性脑肿瘤。铊-201的生物学特性使其能够在肿瘤细胞内蓄积，这使得铊-201在评估肿瘤恶性程度方面很有用，但与锝-99m标记的化合物相比，其物理特性和非常规可得性限制了它在一些机构中的应用。本研究的目的是评估使用锝-99m-替曲膦进行脑肿瘤成像的可行性，并将其摄取情况与铊-201的摄取情况进行比较。
对26例患有27个颅内肿块的患者进行单光子发射计算机断层扫描（SPECT）研究。在第一组7例患者（A组）中，评估了锝-99m-替曲膦扫描的最佳采集时间。在第二组19例患者（B组）中，在注射示踪剂20分钟后，依次进行了两次研究，分别注射铊-201（74 - 148兆贝可静脉注射）和锝-99m-替曲膦（740 - 925兆贝可静脉注射），并进行比较。
在A组中，注射后20分钟、4
