起始子结合蛋白TFII-I和YY-1的多个结构域存在于大鼠XDH/XO无TATA启动子的起始子及上游区域。
Multiple domains for initiator binding proteins TFII-I and YY-1 are present in the initiator and upstream regions of the rat XDH/XO TATA-less promoter.
作者信息
Clark M P, Chow C W, Rinaldo J E, Chalkley R
机构信息
Nashville VA Medical Center, Department of Medicine, School of Medicine, Vanderbilt University, Nashville, TN 37237, USA.
出版信息
Nucleic Acids Res. 1998 Jun 1;26(11):2813-20. doi: 10.1093/nar/26.11.2813.
Abstract
We previously reported that the TATA-less rat xanthine dehydrogenase/oxidase (XDH/XO) promoter is organized with multiple initiator elements (Inr 1, 2, 3 and 4). Additionally, we identified six factor binding footprints in the upstream region of this promoter (FP 1-FP 6), two of which (FP 2 and FP 4) we showed to be C/EBP binding sites. In this report we continue our characterization of the XDH/XO promoter, detailing other cis elements which comprise the Inr and upstream binding factors. Interestingly, multiple binding domains for known initiator binding proteins, YY-1 and USF-related factor/TFII-I, have been identified which potentially play an important role in transcription initiation.
摘要
我们之前报道过，无TATA盒的大鼠黄嘌呤脱氢酶/氧化酶（XDH/XO）启动子由多个起始子元件（Inr 1、2、3和4）组成。此外，我们在该启动子的上游区域鉴定出六个因子结合足迹（FP 1-FP 6），其中两个（FP 2和FP 4）被证明是C/EBP结合位点。在本报告中，我们继续对XDH/XO启动子进行表征，详细阐述构成起始子和上游结合因子的其他顺式元件。有趣的是，已鉴定出已知起始子结合蛋白YY-1和USF相关因子/TFII-I的多个结合结构域，它们可能在转录起始中发挥重要作用。
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本文引用的文献
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2
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EMBO J. 1993 Feb;12(2):501-11. doi: 10.1002/j.1460-2075.1993.tb05682.x.
3
An alternative pathway for transcription initiation involving TFII-I.一种涉及TFII-I的转录起始替代途径。
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4
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