Fuchs P C, Barry A L, Brown S D
The Clinical Microbiology Institute, Wilsonville, Oregon 97070, USA.
Antimicrob Agents Chemother. 1998 May;42(5):1213-6. doi: 10.1128/AAC.42.5.1213.
MSI-78 is a cationic peptide with broad-spectrum antimicrobial activity and is being developed as a topical agent. We compared the in vitro activity of MSI-78 with those of ofloxacin and other antibiotics against fresh clinical isolates. Based on MIC distribution statistics, strains for which the MSI-78 MIC was < or = 64 micro/ml were assumed to be susceptible for purposes of this report. Of 411 aerobic isolates tested, 91% were susceptible to MSI-78, compared to 91% for ofloxacin and 92% for ciprofloxacin. Only enterococci consistently required > or = 64 microg of MSI-78/ml for inhibition. MSI-78 demonstrated bactericidal activity equivalent to that of ofloxacin. Of 61 anaerobes, 97% were susceptible to MSI-78. Of 10 isolates of Candida albicans, 3 were inhibited by MSI-78 at 24 h. Further studies of this compound appear to be warranted.
MSI-78是一种具有广谱抗菌活性的阳离子肽，目前正作为一种局部用药进行研发。我们比较了MSI-78与氧氟沙星及其他抗生素对新鲜临床分离株的体外活性。基于最小抑菌浓度（MIC）分布统计，本报告中MSI-78的MIC≤64微克/毫升的菌株被视为敏感菌株。在411株需氧菌分离株的检测中，91%对MSI-78敏感，氧氟沙星的敏感率为91%，环丙沙星为92%。只有肠球菌始终需要≥64微克的MSI-78/毫升才能被抑制。MSI-78显示出与氧氟沙星相当的杀菌活性。在61株厌氧菌中，97%对MSI-78敏感。在10株白色念珠菌分离株中，有3株在24小时时被MSI-78抑制。对该化合物进行进一步研究似乎是有必要的。
