司帕沙星、环丙沙星、氧氟沙星及其他抗生素对革兰氏阳性球菌血流感染分离株的体外活性

In vitro activity of sparfloxacin, ciprofloxacin, ofloxacin, and other antibiotics against bloodstream isolates of gram-positive cocci.

作者信息

Rotstein C, Amsterdam D, Beam T R, Mandell L A, Gorzynski E A

机构信息

Division of Infectious Diseases, McMaster University, Hamilton, Ontario, Canada.

出版信息

Diagn Microbiol Infect Dis. 1993 Jul;17(1):85-91. doi: 10.1016/0732-8893(93)90077-k.

DOI:10.1016/0732-8893(93)90077-k

PMID:8395375

Abstract

The in vitro activity of sparfloxacin was compared with the activities of ciprofloxacin, ofloxacin, and six other antimicrobial agents against 323 bloodstream isolates of staphylococci (both oxacillin susceptible and resistant) enterococci, and pneumococci. Sparfloxacin was more active than both ciprofloxacin and ofloxacin against all the isolates tested. Its activity (MIC for 90% of strains tested < or = 0.10 microgram/ml) against oxacillin-susceptible staphylococci was superior to that of ciprofloxacin and ofloxacin by at least fourfold. Sparfloxacin was also more potent against pneumococci. However, fluoroquinolone resistance was noted among oxacillin-resistant strains of Staphylococcus aureus and coagulase-negative staphylococci.

摘要

将司帕沙星的体外活性与环丙沙星、氧氟沙星及其他六种抗菌药物对323株血流感染分离株（包括对苯唑西林敏感和耐药的葡萄球菌、肠球菌及肺炎球菌）的活性进行了比较。司帕沙星对所有测试分离株的活性均高于环丙沙星和氧氟沙星。其对苯唑西林敏感葡萄球菌的活性（90%测试菌株的MIC≤0.10微克/毫升）比环丙沙星和氧氟沙星至少强四倍。司帕沙星对肺炎球菌也更具活性。然而，在耐苯唑西林的金黄色葡萄球菌和凝固酶阴性葡萄球菌菌株中发现了氟喹诺酮耐药性。