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左氧氟沙星与氧氟沙星、环丙沙星、红霉素、阿奇霉素及克拉霉素相比，对20株肺炎球菌的抗生素后效应及抗生素后亚抑菌浓度效应

Postantibiotic effect and postantibiotic sub-MIC effect of levofloxacin compared to those of ofloxacin, ciprofloxacin, erythromycin, azithromycin, and clarithromycin against 20 pneumococci.

作者信息

Spangler S K, Lin G, Jacobs M R, Appelbaum P C

机构信息

Department of Pathology (Clinical Microbiology), Hershey Medical Center, Pennsylvania 17033, USA.

出版信息

Antimicrob Agents Chemother. 1998 May;42(5):1253-5. doi: 10.1128/AAC.42.5.1253.

DOI:10.1128/AAC.42.5.1253
PMID:9593160
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC105793/
Abstract

The postantibiotic effect (PAE) (10 times the MIC of quinolones, 5 times the MIC of macrolides) and postantibiotic sub-MIC effect (PAE-SME) at 0.125, 0.25, and 0.5 times the MIC were determined for levofloxacin, ciprofloxacin, ofloxacin, erythromycin, azithromycin, and clarithromycin against 20 pneumococci. Quinolone PAEs ranged between 0.5 and 6.5 h, and macrolide PAEs ranged between 1 and 6 h. Measurable PAE-SMEs (in hours) at the three concentrations were 1 to 5, 1 to 8, and 1 to 8, respectively, for quinolones and 1 to 8, 1 to 8, and 1 to 6, respectively, for macrolides.

摘要

测定了左氧氟沙星、环丙沙星、氧氟沙星、红霉素、阿奇霉素和克拉霉素对20株肺炎球菌的抗生素后效应（PAE）（喹诺酮类为最低抑菌浓度的10倍，大环内酯类为最低抑菌浓度的5倍）以及在最低抑菌浓度的0.125、0.25和0.5倍时的抗生素后亚最低抑菌浓度效应（PAE-SME）。喹诺酮类的PAE范围为0.5至6.5小时，大环内酯类的PAE范围为1至6小时。喹诺酮类在三种浓度下可测量的PAE-SME（以小时计）分别为1至5、1至8和1至8，大环内酯类分别为1至8、1至8和1至6。

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