Ogawa A, Maeguchi M, Uchida Y, Yoshioka T, Kawashima M, Muraki T
Department of Pharmacology, Tokyo Women's Medical University, Japan.
Jpn J Pharmacol. 1998 Mar;76(3):317-9. doi: 10.1254/jjp.76.317.
The inhibitory effect of tazarotene, an acetylenic retinoid, on human dermal fibroblast in vitro was compared to that of all-trans-retinoic acid. The proliferation of fibroblasts was inhibited by both retinoids at the concentration of 1 microM after 5 days of culture. Synthesis of DNA and collagen was inhibited by both retinoids concentration-dependently up to 10 microM, although tazarotene was weaker in the inhibition of collagen synthesis. These results suggest the possible usefulness of tazarotene in the treatment of fibrotic diseases.
将乙炔类维甲酸他扎罗汀对人皮肤成纤维细胞的体外抑制作用与全反式维甲酸进行了比较。培养5天后，两种维甲酸在1微摩尔浓度时均抑制成纤维细胞的增殖。两种维甲酸对DNA和胶原蛋白合成的抑制均呈浓度依赖性，最高可达10微摩尔，不过他扎罗汀在抑制胶原蛋白合成方面较弱。这些结果表明他扎罗汀在治疗纤维化疾病方面可能有用。
