Daly T J, Weston W L
J Am Acad Dermatol. 1986 Oct;15(4 Pt 2):900-2. doi: 10.1016/s0190-9622(86)70248-x.
There are relatively few studies of the effect of retinoids on dermal tissue. A selective review of the literature reveals that when retinoids, especially all-trans-retinoic acid (tretinoin), are exposed to cultured human fibroblasts, they produce a marked reduction of fibroblast proliferation and collagen synthesis. Our clinical study of keloids and hypertrophic scars demonstrates in vivo effects of retinoids that are consistent with the in vitro data. Retinoids have significant clinical activity on dermal tissue, and further in vitro and in vivo development and testing of retinoids may lead to significant therapeutic advances in the treatment of fibrotic diseases.
关于维甲酸对皮肤组织影响的研究相对较少。对文献的选择性回顾显示，当维甲酸，尤其是全反式维甲酸（维甲酸）作用于培养的人成纤维细胞时，它们会显著降低成纤维细胞的增殖和胶原蛋白的合成。我们对瘢痕疙瘩和增生性瘢痕的临床研究证明了维甲酸在体内的作用与体外数据一致。维甲酸对皮肤组织具有显著的临床活性，维甲酸进一步的体外和体内研发及测试可能会在纤维化疾病的治疗方面带来重大的治疗进展。
