Tecklin J S, Holsclaw D S
Phys Ther. 1976 Sep;56(9):999-1003. doi: 10.1093/ptj/56.9.999.
Examined in this study are the immediate effects of bronchial drainage preceded by the inhalation of aerosol solutions of a mucolytic agent, a bronchodilator, and their combination upon four measures of pulmonary function in 20 patients with cystic fibrosis. On three separate occasions, pulmonary function was tested preceding and following treatments consisting of one of the above three aerosol solutions followed by bronchial drainage. The order of solutions used was random and each subject received one treatment with each solution. The greatest overall improvement in function was seen with the bronchodilator and bronchial drainage. The combination of the bronchodilator/mucolytic agents and bronchial drainage was the next most effective technique. The mucolytic agent, when used alone with bronchial drainage, decreased function. Comparison of the pulmonary function scores indicated a significant difference among the three treatments.
本研究考察了在20名囊性纤维化患者中，在进行支气管引流之前吸入黏液溶解剂气雾剂溶液、支气管扩张剂气雾剂溶液及其组合对四项肺功能指标的即时影响。在三个不同的时间段，分别在由上述三种气雾剂溶液之一随后进行支气管引流的治疗之前和之后测试肺功能。所用溶液的顺序是随机的，每个受试者接受每种溶液的一次治疗。支气管扩张剂和支气管引流使功能得到最大程度的整体改善。支气管扩张剂/黏液溶解剂与支气管引流的组合是次有效的技术。黏液溶解剂单独与支气管引流使用时，功能下降。肺功能评分的比较表明三种治疗之间存在显著差异。
