Jabłońska B, Smith A L, Kossut M, Skangiel-Kramska J
Department of Neurophysiology, Nencki Institute of Experimental Biology, 3 Pasteur St., 02-093 Warsaw, Poland.
Brain Res. 1998 Apr 27;791(1-2):325-9. doi: 10.1016/s0006-8993(98)00200-5.
Kainate receptors were present at birth in the murine somatosensory cortex as revealed by quantitative in vitro autoradiography. During the first five postnatal days [3H]kainate binding rapidly increased and the maximum density in layer IV was reached at P12. The adult laminar pattern of receptor binding distribution was established by the third postnatal week with the heaviest labeling of infragranular layers. The sharp increase of kainate receptor during the first postnatal week coincides with the critical period for cytoarchitectonic plasticity of the barrels and establishment of functional thalamo-cortical connections in the barrel field.
定量体外放射自显影显示，海人酸受体在小鼠体感皮层出生时就已存在。在出生后的前五天，[3H]海人酸结合迅速增加，在出生后第12天达到IV层的最大密度。出生后第三周建立了受体结合分布的成年分层模式，颗粒下层标记最重。出生后第一周海人酸受体的急剧增加与桶状结构细胞构筑可塑性的关键期以及桶状区域功能性丘脑-皮质连接的建立相吻合。
