Grunze H, Greene R W, Möller H J, Meyer T, Walden J
Psychiatrische Klinik der Universität, Nussbaumstr. 7, 80336 München, Germany.
Brain Res. 1998 Apr 27;791(1-2):330-4. doi: 10.1016/s0006-8993(98)00180-2.
Actions of the new antiepileptic drug lamotrigine were characterised using whole cell patch clamp recordings from rat CA1 pyramidal cells in vitro. The results suggest that lamotrigine, besides its previously described effect on the fast sodium inward current and calcium currents, modulates the transient potassium outward current ID. This may be an effective mechanism to inhibit pathological excitation.
利用体外大鼠CA1锥体神经元的全细胞膜片钳记录技术，对新型抗癫痫药物拉莫三嗪的作用进行了特性研究。结果表明，拉莫三嗪除了对快速内向钠电流和钙电流有先前描述的作用外，还可调节瞬时外向钾电流ID。这可能是抑制病理性兴奋的一种有效机制。
