Grunze H, von Wegerer J, Greene R W, Walden J
Psychiatrische Klinik der Universität, München, Deutschland.
Neuropsychobiology. 1998 Oct;38(3):131-8. doi: 10.1159/000026528.
Actions of the new antiepileptic drug lamotrigine (LTG) were characterized using extracellular and whole cell patch clamp recordings from rat CA1 and CA3 pyramidal cells in vitro. The results suggest that LTG, beside its previously described effect on the fast sodium inward current, also modulates - presumably voltage-gated - calcium currents and the transient potassium outward current ID. These may be effective mechanisms to inhibit pathological excitation in epilepsy and may be of potential benefit in treating underlying cellular disturbances in bipolar disorder.
利用体外大鼠CA1和CA3锥体细胞的细胞外和全细胞膜片钳记录，对新型抗癫痫药物拉莫三嗪（LTG）的作用进行了表征。结果表明，LTG除了其先前描述的对快速钠内向电流的作用外，还调节——可能是电压门控的——钙电流和瞬时钾外向电流ID。这些可能是抑制癫痫病理兴奋的有效机制，并且可能对治疗双相情感障碍的潜在细胞紊乱有益。
