Bonnin M R, Moragues C, Nolla J M, Lirón F J, Roig-Escofet D, Navarro M A
Hormone Unit, Ciudad Sanitaria y Universitaria de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.
Clin Chem Lab Med. 1998 Jan;36(1):53-5. doi: 10.1515/CCLM.1998.010.
We evaluated circulating aminoterminal and carboxyterminal propeptides of type I procollagen and total alkaline phosphatase levels in eighty consecutive patients affected by Paget's disease of bone. We compared the biochemical data with the extent of bone disease calculated on the basis of the bone scintigraphic indices. Serum aminoterminal propeptide of type I procollagen levels were high in 77% of patients, serum carboxyterminal propeptide of type I procollagen levels in 22% and serum total alkaline phosphatase levels in 76%. We found significant correlations between the three markers studied. The three biochemical markers correlated significantly with the bone scintigraphic activity indices, but the highest correlation coefficient was between the aminoterminal propeptide and total alkaline phosphatase. We conclude that there is a discrepancy between serum levels of the propeptides studied in relation to Paget's disease of bone. The sensitivity of the carboxyterminal propeptide of type I procollagen in this disease is low. In contrast the aminoterminal propeptide may be as sensitive a marker for the evaluation of this disorder as total alkaline phosphatase, and in addition may be more specific.
我们评估了80例连续性骨Paget病患者的血清I型前胶原氨基端和羧基端前肽以及总碱性磷酸酶水平。我们将这些生化数据与基于骨闪烁显像指数计算的骨病范围进行了比较。77%的患者血清I型前胶原氨基端前肽水平升高，22%的患者血清I型前胶原羧基端前肽水平升高，76%的患者血清总碱性磷酸酶水平升高。我们发现所研究的三种标志物之间存在显著相关性。这三种生化标志物与骨闪烁显像活性指数显著相关，但氨基端前肽与总碱性磷酸酶之间的相关系数最高。我们得出结论，在所研究的与骨Paget病相关的前肽血清水平之间存在差异。I型前胶原羧基端前肽在该疾病中的敏感性较低。相比之下，氨基端前肽作为评估这种疾病的标志物可能与总碱性磷酸酶一样敏感，此外可能更具特异性。
