Halawa B, Mazurek W
Katedra i Klinika Kardiologii AM we Wrocławiu.
Pol Arch Med Wewn. 1997 Nov;98(11):407-13.
Obesity increases the risk of developing hypertension by two-to fourfold, with more that one third of all cases of hypertension attributable to obesity. The present study tested the role of atrial natriuretic peptide (ANP), endothelin-1,2 (ET-1,2) and neuropeptide Y (NPY) in pathogenesis of obesity hypertension. The plasma concentrations of ANP, ET-1,2 and NPY were determined in the peripheral venous blood by radioimmunoassay in 27 obese hypertensive patients (group I), in 24 obese normotensive patients (group II), and in 35 normal subjects (group III).
Mean plasma ANP was significantly higher in obese than in normal subjects. ANP levels were higher in patients group I than in those group II and I. In patients of group I plasma ANP concentrations correlated with III BMI and mean blood pressure. Plasma levels of ET-1,2 and NPY were similar in patients group I, II and III.
肥胖使患高血压的风险增加两到四倍，所有高血压病例中有超过三分之一可归因于肥胖。本研究检测了心房利钠肽（ANP）、内皮素-1,2（ET-1,2）和神经肽Y（NPY）在肥胖性高血压发病机制中的作用。通过放射免疫分析法测定了27例肥胖高血压患者（I组）、24例肥胖血压正常患者（II组）和35名正常受试者（III组）外周静脉血中ANP、ET-1,2和NPY的血浆浓度。
肥胖患者的平均血浆ANP显著高于正常受试者。I组患者的ANP水平高于II组和III组患者。在I组患者中，血浆ANP浓度与BMI和平均血压相关。I、II、III组患者的ET-1,2和NPY血浆水平相似。
