Koss M C, Nakano J, Rieger J A
Prostaglandins. 1976 Apr;11(4):691-8. doi: 10.1016/0090-6980(76)90069-1.
Intravenous injection of prostaglandin F2alpha (4-15 mug/kg, i.v.) produces an increase in pulmonary arterial pressure in conjunction with reflex bradycardia and hypotension in the anesthetized cat. Meclofenamic acid (30 mg/kg, i.v.) inhibited the bradycardia and the reflex contribution to the systemic hypotension. Neither the PGF2alpha-induced pulmonary vasoconstriction nor the direct systemic vasodilator actions of PGF2alpha were blocked by meclofenamate. In addition, the reflex responses caused by i.v. veratrine and 5-HT were not inhibited by meclofenamate. These results suggest that meclofenamic acid selectively blocks the afferent mechanism by which PGF2alpha induces reflex bradycardia and hypotension in the cat.
静脉注射前列腺素F2α（4 - 15微克/千克，静脉注射）会使麻醉猫的肺动脉压升高，同时伴有反射性心动过缓和低血压。甲氯芬那酸（30毫克/千克，静脉注射）可抑制心动过缓和对全身性低血压的反射作用。甲氯芬那酸既不阻断前列腺素F2α诱导的肺血管收缩，也不阻断前列腺素F2α的直接全身性血管舒张作用。此外，静脉注射藜芦碱和5 - 羟色胺引起的反射反应也不受甲氯芬那酸抑制。这些结果表明，甲氯芬那酸选择性地阻断了前列腺素F2α在猫体内诱导反射性心动过缓和低血压的传入机制。
