Koss M C
Prostaglandins. 1976 Dec;12(6):997-1004. doi: 10.1016/0090-6980(76)90133-7.
Prostaglandin F2alpha (5mug/kg, i.v.) causes an increase in pulmonary arterial pressure, decrease in systemic arterial pressure, and reflex bradycardia in the anesthetized cat. The same dose of the 15-methyl analogue of PGF2alpha produces the same triad of effects but of greater magnitude and duration. Although prostaglandins F1alpha, F2beta and F1beta also cause the same cardiovascular effects as F2alpha, there is a decrease in potency for all parameters measured, with PGF2alpha greater than PGF1alpha greater than PGF2beta greater than PGF 1beta. When compared to the actions of PGF2alpha in producing an increase in pulmonary arterial pressure, PGs F1alpha, F2beta and F1beta were less potent by approximately 10, 100, and 1000 fold respectively.
前列腺素F2α（5微克/千克，静脉注射）可使麻醉猫的肺动脉压升高、体动脉压降低并出现反射性心动过缓。相同剂量的PGF2α的15 - 甲基类似物会产生相同的三联效应，但程度更强且持续时间更长。虽然前列腺素F1α、F2β和F1β也会产生与F2α相同的心血管效应，但在所测量的所有参数方面效力均降低，PGF2α＞PGF1α＞PGF2β＞PGF1β。与PGF2α升高肺动脉压的作用相比，PGF1α、F2β和F1β的效力分别约低10倍、100倍和1000倍。
