Karppanen H, Sirén A L, Eskeli-Kaivosoja A
Prostaglandins. 1979 Mar;17(3):385-94. doi: 10.1016/s0090-6980(79)80006-4.
Administration of PGF2 ALPHA (0.2--6.4 micrograms) into the lateral cerebral ventricle (i.c.v.) induced dose-dependent increases in blood pressure, heart rate and body temperature in urethane-anaesthetised rats, but had no effect on these parameters when the same dose range was administered intravenously. Peripheral pretreatment with sodium meclofenamate (50 mg/kg s.c.) shifted all the dose-response curves for PGF2 alpha (i.c.v.) to the left, but indomethacin (50 mg/kg s.c.) did not significantly affect those changes. Central pretreatment with sodium meclofenamate or indomethacin (1.25 mg per rat i.c.v.) failed to modify significantly the effects of centrally administered PGF2 alpha. The results support previous suggestions that PGF2 alpha may participate in the central control of the cardiovascular and thermoregulatory systems, and also suggest that there may be differences in the sites and/or modes of action between sodium meclofenamate and indomethacin.
向氨基甲酸乙酯麻醉的大鼠侧脑室（脑室内）注射前列腺素F2α（0.2 - 6.4微克）可引起血压、心率和体温呈剂量依赖性升高，但静脉注射相同剂量范围时对这些参数无影响。甲氯芬那酸钠（50毫克/千克，皮下注射）进行外周预处理可使前列腺素F2α（脑室内）的所有剂量反应曲线左移，但吲哚美辛（50毫克/千克，皮下注射）对这些变化无显著影响。甲氯芬那酸钠或吲哚美辛（每只大鼠1.25毫克，脑室内注射）进行中枢预处理未能显著改变脑室内注射前列腺素F2α的作用。结果支持了先前的观点，即前列腺素F2α可能参与心血管和体温调节系统的中枢控制，并且还表明甲氯芬那酸钠和吲哚美辛在作用部位和/或作用方式上可能存在差异。
