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羊膜腔内注射15-甲基前列腺素F2α引产的动力学和代谢研究。

Kinetic and metabolic studies of 15-methyl-prostaglandin F2alpha administered intra-amniotically for induction of abortion.

作者信息

Gréen K, Granström E, Bygdeman M, Wiqvist N

出版信息

Prostaglandins. 1976 Apr;11(4):699-711. doi: 10.1016/0090-6980(76)90070-8.

DOI:10.1016/0090-6980(76)90070-8
PMID:959571
Abstract

The metabolism of tritium labeled 15-methyl-PGF2alpha, administered intra-amniotically, was studied in seven cases of mid-trimester abortion. The disappearance of the compound from the amniotic sac was a very slow process. A metabolite, dinor-15-methyl-PGF2alpha, was found in small amounts in the amniotic and kidney. Plasma levels of 15-methyl-PGF2alpha in the maternal circulation were determined.

摘要

对7例孕中期流产病例进行了研究，观察羊膜腔内注射氚标记的15-甲基-PGF2α后的代谢情况。该化合物从羊膜囊消失是一个非常缓慢的过程。在羊水和肾脏中发现了少量代谢产物二降-15-甲基-PGF2α。测定了母体循环中15-甲基-PGF2α的血浆水平。

相似文献

1
Kinetic and metabolic studies of 15-methyl-prostaglandin F2alpha administered intra-amniotically for induction of abortion.羊膜腔内注射15-甲基前列腺素F2α引产的动力学和代谢研究。
Prostaglandins. 1976 Apr;11(4):699-711. doi: 10.1016/0090-6980(76)90070-8.
2
Disappearance of prostaglandins F2alpha and 15-methyl F2alpha from amniotic fluid as measured by radiommunoassay.通过放射免疫分析法测定羊水前列腺素F2α和15-甲基F2α的消失情况。
Prostaglandins. 1975 Nov;10(5):865-75. doi: 10.1016/0090-6980(75)90014-3.
3
Prostaglandin F2alpha disappearance and concentration in amniotic fluid and blood of women undergoing abortion with intra-amniotic hypertonic saline.羊膜腔内注入高渗盐水进行流产的妇女羊水中和血液中前列腺素F2α的消失及浓度
Contraception. 1975 Dec;12(6):679-96. doi: 10.1016/s0010-7824(75)80051-5.
4
Prostaglandins and abortion. III. Comparison of single intra-amniotic injections of 15-methyl prostaglandin F2alpha and prostaglandin F2alpha for termination of second-trimester pregnancy: an international multicenter study. World Health Organization Tast Force on the Use of Prostaglandins forthe Regulation of Fertility.前列腺素与堕胎。III. 羊膜腔内单次注射15-甲基前列腺素F2α和前列腺素F2α终止中期妊娠的比较：一项国际多中心研究。世界卫生组织前列腺素用于调节生育问题特别工作组。
Am J Obstet Gynecol. 1977 Nov 15;129(6):601-6.
5
Induction of abortion with intra-amniotic or intra-muscular 15(S)-15-methyl-prostaglandin F2alpha.羊膜腔内或肌肉注射15(S)-15-甲基前列腺素F2α引产。
Prostaglandins. 1975 Sep;10(3):423-34. doi: 10.1016/0090-6980(75)90124-0.
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Intra-amniotic administration of 15(S)-15-methyl-prostaglandin F2alpha for the induction of midtrimester abortion.羊膜腔内注射15(S)-15-甲基前列腺素F2α用于中期妊娠引产。
Am J Obstet Gynecol. 1976 Jul 15;125(6):821-6. doi: 10.1016/0002-9378(76)90857-7.
7
[Intra-amniotic administration of prostaglandin F 2 alpha, 12-methyl-prostaglandin F 2 alpha and hypertonic sodium chloride solution for induction of abortion in second-trimester pregnancy].羊膜腔内注射前列腺素F2α、12-甲基前列腺素F2α及高渗氯化钠溶液用于中期妊娠引产
Zentralbl Gynakol. 1975;97(19):1153-9.
8
Midtrimester intra-aminotic administration of prostaglandin F2alpha in combination with an hyperosmolar urea solution: effect upon plasma levels of estradiol, progesterone, and human placental lactogen (HPL).孕中期羊膜腔内注射前列腺素F2α联合高渗尿素溶液：对雌二醇、孕酮和人胎盘催乳素（HPL）血浆水平的影响。
Acta Obstet Gynecol Scand. 1978;57(3):223-5. doi: 10.3109/00016347809154886.
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Administration of prostaglandins by various routes for induction of abortion. Merits and demerits.通过各种途径给予前列腺素以诱导流产。优点和缺点。
Prostaglandins. 1978 Apr;15(4):685-93. doi: 10.1016/0090-6980(78)90065-5.
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Midtrimester abortion induced by single intra-amniotic instillation of two dose schedules of 15(S)-15-methyl-prostaglandin F2alpha.通过羊膜腔内单次注入两种剂量方案的15（S）-15-甲基前列腺素F2α诱导中期妊娠流产。
Prostaglandins. 1975 Apr;9(4):617-25. doi: 10.1016/0090-6980(75)90067-2.

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