Kinetic and metabolic studies of 15-methyl-prostaglandin F2alpha administered intra-amniotically for induction of abortion.

The metabolism of tritium labeled 15-methyl-PGF2alpha, administered intra-amniotically, was studied in seven cases of mid-trimester abortion. The disappearance of the compound from the amniotic sac was a very slow process. A metabolite, dinor-15-methyl-PGF2alpha, was found in small amounts in the amniotic and kidney. Plasma levels of 15-methyl-PGF2alpha in the maternal circulation were determined.