Salmon J A, Karim S M
Prostaglandins. 1975 Nov;10(5):865-75. doi: 10.1016/0090-6980(75)90014-3.
A sensitive and relatively specific radioimmunoassay for 15 (S) 15 methyl prostaglandin F2alpha was used to determine the levels of the drug in amniotic fluid after it had been injected intra-amniotically for termination of second trimester pregnancy. The disappearance of the free acid (tham salt) and methyl ester of the prostaglandin analogue were similar. The results of this preliminary study suggest that the drug rapidly equilibrates in the fluid and this followed by a slow removal from the amniotic sac. A comparison with a similar study with PGF2Alpha revealed that the analogue had a longer half-life in the amniotic fluid.
采用一种灵敏且相对特异的放射免疫分析法测定15（S）-15-甲基前列腺素F2α，在经羊膜腔内注射该药物以终止中期妊娠后，检测羊水内该药物的水平。前列腺素类似物的游离酸（三羟甲基氨基甲烷盐）和甲酯的消失情况相似。这项初步研究结果表明，该药物在羊水中迅速达到平衡，随后从羊膜囊中缓慢清除。与一项关于前列腺素F2α的类似研究相比，该类似物在羊水中的半衰期更长。
