Antonelli P J, Nall A V, Lemmerling M M, Mancuso A A, Kubilis P S
Department of Otolaryngology, University of Florida College of Medicine, Gainesville 32610-0264, USA.
Am J Otol. 1998 May;19(3):306-12.
Defects of the cochlear modiolus have been found to be associated with most cases of large vestibular aqueduct. The clinical significance of these modiolar defects has not been studied previously. The purpose of this article is to correlate clinical (functional) parameters, such as hearing outcomes, with the severity of the radiographic findings in these dysplastic inner ears.
The study design was a retrospective chart review, supplemented with telephone interviews and clinic visits.
The study was conducted at an academic, tertiary care center.
Thirty consecutive patients with large vestibular aqueducts participated.
Scores of modiolar deficiencies yielded inconsistent correlations with hearing loss. Vestibular aqueduct morphology and thickness correlated very strongly with the severity of hearing loss.
These observations support the hypothesis that large vestibular aqueduct-related hearing loss may be caused by transmission of subarachnoid pressure forces into the inner ear. However, the thickness and morphology of the vestibular aqueduct may simply be markers for more subtle cochlear dysplasia manifest by modiolar deficiency.
已发现耳蜗蜗轴缺陷与大多数大前庭导水管病例相关。此前尚未对这些蜗轴缺陷的临床意义进行研究。本文的目的是将听力结果等临床（功能）参数与这些发育异常的内耳的影像学检查结果的严重程度相关联。
研究设计为回顾性病历审查，并辅以电话访谈和门诊就诊。
该研究在一家学术性三级医疗中心进行。
连续30例大前庭导水管患者参与研究。
蜗轴缺陷评分与听力损失的相关性不一致。前庭导水管形态和厚度与听力损失的严重程度密切相关。
这些观察结果支持以下假设，即大前庭导水管相关的听力损失可能是由蛛网膜下腔压力传入内耳所致。然而，前庭导水管的厚度和形态可能仅仅是蜗轴缺陷所表现出的更细微的耳蜗发育异常的标志。
