Ménard A, Pierig R, Pelletier J, Bensa P, Belliveau J, Mandrand B, Perron H, Rieger F
INSERM Laboratoire de Neuromodulations Interactives et Neuropathologies - 17, Paris, France.
Neurosci Lett. 1998 Mar 27;245(1):49-52. doi: 10.1016/s0304-3940(98)00171-2.
We recently showed that peripheral blood cell supernatants from multiple sclerosis (MS) patients, containing reverse transcriptase activity and retroviral RNA from the newly human identified multiple sclerosis retrovirus (MSRV), also secrete a cytotoxin which induces death of primary mouse cortical glial cells. We have hypothesized that macrophages could release this cytotoxin in the cerebrospinal fluid. The cerebrospinal fluid cytotoxicity from 166 patients with various neurological diseases (including MS patients) was tested on glial cells in vitro. Our bioassay shows that a glial cytotoxic activity is significantly present in cerebrospinal fluid from patients with relapsing-remitting MS at relapse. Since this cytotoxic activity seems to correlate with active cases of MS, it may represent a critical pathogenic factor in the neuropathology of MS.
我们最近发现，来自多发性硬化症（MS）患者的外周血细胞上清液含有逆转录酶活性以及来自新发现的人类多发性硬化症逆转录病毒（MSRV）的逆转录病毒RNA，同时还分泌一种可诱导原代小鼠皮质神经胶质细胞死亡的细胞毒素。我们推测巨噬细胞可能会在脑脊液中释放这种细胞毒素。对166例患有各种神经系统疾病（包括MS患者）的患者的脑脊液进行了体外神经胶质细胞毒性测试。我们的生物测定表明，复发缓解型MS患者复发时的脑脊液中存在显著的神经胶质细胞毒性活性。由于这种细胞毒性活性似乎与MS的活动病例相关，它可能是MS神经病理学中的一个关键致病因素。
