Mar P, Gradl T, Dörner C
J Neurol Sci. 1979 May;41(3):369-77. doi: 10.1016/0022-510x(79)90096-0.
Complement-dependent gliotoxic antibody activity was determined in 22 patients with multiple sclerosis (MS) and 19 normal control persons. Peripheral blood serum was collected from MS patients at about 4-week intervals for one year, and the results of cytotoxicity tests correlated with the course of disease. For 10 MS patients with stable disease, complement-dependent cytotoxic antibodies directed against a noncytocidally infected mouse glial cell line (an as yet unidentified virus) were found in significantly higher than normal titer. For 12 MS patients with fluctuating clinical course, the gliotoxic antibody titer remained relatively constant before relapse. During relapse, the titer remained constant or dropped. With remission initially low titers increased appreciably.
在22例多发性硬化症（MS）患者和19名正常对照者中测定了补体依赖性神经毒性抗体活性。对MS患者每隔约4周采集外周血血清，持续一年，细胞毒性试验结果与病程相关。在10例病情稳定的MS患者中，发现针对非杀细胞性感染的小鼠神经胶质细胞系（一种尚未鉴定的病毒）的补体依赖性细胞毒性抗体滴度显著高于正常水平。在12例临床病程波动的MS患者中，神经毒性抗体滴度在复发前保持相对稳定。复发期间，滴度保持不变或下降。缓解期开始时，低滴度会明显升高。
