Smiley K A, Karler R, Turkanis S A
Res Commun Chem Pathol Pharmacol. 1976 Aug;14(4):659-75.
In the isolated perfused rat heart cardiac rate and contractility are directly affected by four naturally occurring cannabis constituents, delta9-tetrahydrocannabinol, delta8-tetrahydrocannabinol, cannabinol and cannabidiol. All the drugs depressed myocardial contractility. Their effect on rate, however, was not uniform: delta8-Tetrahydrocannabinol produced cardiac arrhythmias but no other consistent change; both delta9-tetrahydrocannabinol and cannabinol caused tachycardia; but cannabidiol produced bradycardia, arrhythmias and asystole. In addition, as a consequent of the dispostion of the cannabinoids to accumulate in the isolated heart, high tissue concentrations appeared in conjunction with the direct cardiac effects.
在离体灌注大鼠心脏中，心率和心肌收缩力直接受到四种天然存在的大麻成分的影响，即Δ⁹-四氢大麻酚、Δ⁸-四氢大麻酚、大麻酚和大麻二酚。所有这些药物均降低心肌收缩力。然而，它们对心率的影响并不一致：Δ⁸-四氢大麻酚可导致心律失常，但无其他一致的变化；Δ⁹-四氢大麻酚和大麻酚均可引起心动过速；而大麻二酚则导致心动过缓、心律失常和心脏停搏。此外，由于大麻素在离体心脏中易于蓄积，高组织浓度会伴随直接的心脏效应出现。
