Järbe T U, Henriksson B G, Ohlin G C
Arch Int Pharmacodyn Ther. 1977 Jul;228(1):68-72.
Pigeons, trained to discriminate the effects of i.m. injections of delta9-tetrahydrocannabinol (delta9-THC, 0.25 mg/kg) from the effects of the vehicle in a drug discrimination paradigm, were tested for generalization with the isomeric delta8-THC, cannabidiol (CBD) and cannabinol (CBN). When given in sufficient doses, delta8-THC and CBN were found to substitute for delta9-THC whereas CBD did not. CBD and CBN did not antagonize the stimulus effect of delta9-THC. The combination of CBN and delta9-THC rather appeared to accentuate the drug response.
鸽子经训练后，在药物辨别范式中能够区分肌肉注射Δ⁹ - 四氢大麻酚（Δ⁹ - THC，0.25毫克/千克）与溶剂的效果，随后用异构体Δ⁸ - THC、大麻二酚（CBD）和大麻酚（CBN）对其进行泛化测试。当给予足够剂量时，发现Δ⁸ - THC和CBN可替代Δ⁹ - THC，而CBD则不能。CBD和CBN并未拮抗Δ⁹ - THC的刺激作用。相反，CBN与Δ⁹ - THC的组合似乎增强了药物反应。
