Pulido E, Meot F, Sumano H, Boivin R
Departement de Physiologie, Ecole Nationale Vétérinaire de Lyon, France.
J Vet Pharmacol Ther. 1998 Apr;21(2):138-43. doi: 10.1046/j.1365-2885.1998.00120.x.
Salivary output in sheep is large enough to be considered a physiologic body fluid compartment. The hypothesis for this work was that pharmacokinetics of sulfamethazine in saliva was similar to that in plasma. A reliable technique was developed to measure parotid salivary output. Mean output of saliva was 3.18 +/- 1.04 L from a single parotid gland per day with a mean flow of 2.21 +/- 0.43 mL/min. Using concentrations of sulfamethazine in parotid saliva made it possible to calculate the total passage of sulfamethazine to parotid saliva, which was calculated to be 3.5% of the total dose. Pharmacokinetic variables obtained for sulfamethazine in plasma and in saliva were closely related (AUC 1408 micrograms.h/mL and AUC 1484 micrograms.h/mL; Vdarea 0.434 L/kg and Vdarea 0.374 L/kg; t 1/2 beta 4.30 h and 3.46 h, respectively) and no substantial differences were observed. The convenience of using salivary concentrations of sulfamethazine for drug monitoring is discussed.
绵羊的唾液分泌量足够大，可被视为一个生理体液腔室。这项研究的假设是，磺胺二甲嘧啶在唾液中的药代动力学与在血浆中的相似。开发了一种可靠的技术来测量腮腺唾液分泌量。单个腮腺每天的唾液平均分泌量为3.18±1.04升，平均流速为2.21±0.43毫升/分钟。利用腮腺唾液中磺胺二甲嘧啶的浓度，可以计算出磺胺二甲嘧啶进入腮腺唾液的总量，经计算占总剂量的3.5%。在血浆和唾液中获得的磺胺二甲嘧啶的药代动力学变量密切相关（曲线下面积分别为1408微克·小时/毫升和1484微克·小时/毫升；表观分布容积分别为0.434升/千克和0.374升/千克；消除半衰期分别为4.30小时和3.46小时），未观察到实质性差异。讨论了利用磺胺二甲嘧啶唾液浓度进行药物监测的便利性。
