The oxalate-induced radial segmentation of the nuclei in peripheral blood lymphocytes of different size.

The incidence of oxalate-induced radial-segmented (RS) nuclei in lymphocytes from peripheral blood correlated closely with the diameter of the cell and with the diameter of the nucleus; the majority of RS nuclei were found in large lymphocytes. This observation supports the basic hypotheses, that large lymphocytes from peripheral blood represent a later stage in the cell cycle than small lymphocytes, that the tubulin content of lymphocytes increases during the interphase and that the incidence of RS nuclei reflects the tubulin content of the cells within the various size classes.