Tinahones F J, Vazquez F, Soriguer F J, Collantes E
Section of Endocrinology, Regional Hospital of Málaga, Spain.
Adv Exp Med Biol. 1998;431:61-7. doi: 10.1007/978-1-4615-5381-6_12.
There have been described abnormalities in the lipoprotein profile of hyperuricemic patients, it has not been clarified wether these abnormalities are due to the hyperuricemia or to the dyslipema often associated to these patients. Our aim is to study the apolipoprotein profile in hyperuricemic patients without dyslipemia compared to a control population.
30 hyperuricemic patients and 26 healthy controls. Measurements were of blood uric acid, total cholesterol, total triglycerides, creatinine, HDL-C, and VLDL cholesterol, triglyceride, Apo B, Apo CII and Apo CIII (1 and 2). Uric acid clearance and fractionated excretion were measured in 24 h. urine samples.
No significant differences were found between hyperuricemic and control patients in cholesterol, triglycerides and apo B in VLDL, or LDL and HDL cholesterol. The levels of apo B, Apo AI levels and apo CIII/apo CII were similar in the hyperuricaemic and controls.
There are two types of hyperuricaemic patients, one group associated to hyperlipideamia and would be included in the X Syndrome. The other group not associated to other metabolic abnormalities. Is important to distinguish between these two groups to define the prognosis of a given patient because the greater cardiovascular risk linked hyperuricaemic patients could be related to the association to others cardiovascular risks factors.
已有文献描述了高尿酸血症患者脂蛋白谱的异常，但这些异常是由于高尿酸血症本身还是通常与这些患者相关的血脂异常所致，尚未明确。我们的目的是研究无血脂异常的高尿酸血症患者与对照人群的载脂蛋白谱。
30例高尿酸血症患者和26例健康对照者。检测指标包括血尿酸、总胆固醇、总甘油三酯、肌酐、高密度脂蛋白胆固醇（HDL-C）、极低密度脂蛋白胆固醇、甘油三酯、载脂蛋白B（Apo B）、载脂蛋白CII（Apo CII）和载脂蛋白CIII（Apo CIII，1和2）。在24小时尿样中检测尿酸清除率和分级排泄率。
高尿酸血症患者与对照患者在胆固醇、甘油三酯、极低密度脂蛋白中的载脂蛋白B、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇方面无显著差异。高尿酸血症患者和对照者的载脂蛋白B、载脂蛋白AI水平以及载脂蛋白CIII/载脂蛋白CII水平相似。
高尿酸血症患者有两种类型，一组与高脂血症相关，可归入X综合征。另一组与其他代谢异常无关。区分这两组对于确定特定患者的预后很重要，因为高尿酸血症患者较高的心血管风险可能与合并其他心血管危险因素有关。
