三名播散性莱姆病患者的颅内动脉瘤：病因还是偶然关联？
Intracranial aneurysms in three patients with disseminated Lyme borreliosis: cause or chance association?
作者信息
Oksi J, Kalimo H, Marttila R J, Marjamäki M, Sonninen P, Nikoskelainen J, Viljanen M K
机构信息
Department of Internal Medicine, Turku University Central Hospital, Finland.
出版信息
J Neurol Neurosurg Psychiatry. 1998 May;64(5):636-42. doi: 10.1136/jnnp.64.5.636.
Abstract
METHODS
Three patients with Borrelia burgdorferi infection and intracranial aneurysms are described.
RESULTS
All three patients had neurological symptoms. Perivascular and vasculitic lymphocytic inflammation were detected in the brain biopsy specimen of one patient. The aneurysm was located in the internal carotid arteries in two patients and in the basilar artery in one patient. The aneurysm ruptured in two patients.
CONCLUSIONS
Cerebral lymphocytic vasculitis and intracranial aneurysms may be associated with B burgdorferi infection. It is suggested that inflammatory changes caused by B burgdorferi in vessel walls may be a pathogenetic mechanism for the formation of aneurysms.
摘要
方法
描述了3例感染伯氏疏螺旋体并患有颅内动脉瘤的患者。
结果
所有3例患者均有神经症状。在1例患者的脑活检标本中检测到血管周围和血管炎性淋巴细胞炎症。2例患者的动脉瘤位于颈内动脉，1例患者的动脉瘤位于基底动脉。2例患者的动脉瘤破裂。
结论
脑淋巴细胞性血管炎和颅内动脉瘤可能与伯氏疏螺旋体感染有关。提示伯氏疏螺旋体引起的血管壁炎症改变可能是动脉瘤形成的发病机制。
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