Casteling A, Song E, Sim J, Blaauw D, Heyns A, Schweizer R, Margolius L, Kuun E, Field S, Schoub B, Vardas E
National Institute for Virology, University of the Witwatersrand, Department of Virology, Sandringham, South Africa.
J Med Virol. 1998 Jun;55(2):103-8. doi: 10.1002/(sici)1096-9071(199806)55:2<103::aid-jmv4>3.0.co;2-6.
The prevalence of GBV-C infection in voluntary blood donors and in groups at high risk for parenteral exposure to infectious agents was studied. The high risk groups included chronic renal failure patients on haemodialysis, renal transplant patients and haemophiliacs from Gauteng. The presence of GBV-C RNA in these populations was determined using reverse transcription polymerase chain reaction (RT-PCR) in the 5' non-coding region (NCR) of the virus. Of the blood donors, 11.1% (95% CI 7.6, 15.8) were positive, whereas 23.8% (95% CI 12.6, 40.2) of haemodialysis patients and 23.5% (95% CI 15.9, 33.3) of the haemophiliacs were infected with GBV-C. The highest proportion of infection was in the renal transplant patients, where 41.2% (95% CI 35.1, 47.7) were found to have circulating GBV-C RNA. Serological markers for hepatitis B (HBV) and hepatitis C viruses (HCV) were also measured as indicators of other hepatitis viruses with important parenteral transmission routes. Of the GBV-C positive blood donors, 3.6% were also HBsAg positive and none were positive for HCV. The GBV-C positive patients on haemodialysis were not positive for either HBsAg or antibodies to HCV, but had evidence of past infection with HBV since 40% were anti-HBc positive. The greatest proportion of HCV positives was in the haemophiliac group, 91.3%, none of these were HBsAg positive but 39.1% had anti-HBc. In the GBV-C positive renal transplant patients, 4% had HBsAg, 13.3% had anti-HBc and 2.1% had antibodies to HCV. This is the first report describing the prevalence of GBV-C in South African populations.
研究了自愿献血者以及经肠道外途径接触感染源的高危人群中GBV-C感染的流行情况。高危人群包括豪登省接受血液透析的慢性肾衰竭患者、肾移植患者和血友病患者。使用逆转录聚合酶链反应（RT-PCR）检测病毒5'非编码区（NCR），以确定这些人群中GBV-C RNA的存在情况。在献血者中，11.1%（95%可信区间7.6, 15.8）呈阳性，而血液透析患者中有23.8%（95%可信区间12.6, 40.2）、血友病患者中有23.5%（95%可信区间15.9, 33.3）感染了GBV-C。感染比例最高的是肾移植患者，其中41.2%（95%可信区间35.1, 47.7）被发现循环中有GBV-C RNA。还检测了乙型肝炎（HBV）和丙型肝炎病毒（HCV）的血清学标志物，作为具有重要肠道外传播途径的其他肝炎病毒的指标。在GBV-C阳性的献血者中，3.6%同时HBsAg呈阳性，且无一例HCV呈阳性。接受血液透析的GBV-C阳性患者HBsAg或抗HCV抗体均未呈阳性，但有既往HBV感染的证据，因为40%的患者抗-HBc呈阳性。HCV阳性比例最高的是血友病患者组，为91.3%，这些患者均无HBsAg阳性，但39.1%有抗-HBc。在GBV-C阳性的肾移植患者中，4%有HBsAg，13.3%有抗-HBc，2.1%有抗HCV抗体。这是首份描述南非人群中GBV-C流行情况的报告。
