Riezman H
Biozentrum of the University of Basel, Switzerland.
Semin Cell Dev Biol. 1998 Apr;9(2):129-34. doi: 10.1006/scdb.1997.0217.
G protein-coupled receptors are essential components of the pheromone signaling pathway in Saccharomyces cerevisiae. When ligands bind to these receptors, their down regulation is stimulated. The sequence of events in this process is proposed to be the following: ligand-induced conformational change, receptor hyperphosphorylation and ubiquitination, internalization by an actin-dependent mechanism and subsequent delivery through at least two endocytic intermediates to the vacuole where the receptors are degraded.
G蛋白偶联受体是酿酒酵母中信息素信号通路的重要组成部分。当配体与这些受体结合时，会刺激其下调。该过程中的事件顺序如下：配体诱导的构象变化、受体过度磷酸化和泛素化、通过肌动蛋白依赖性机制内化，随后通过至少两种内吞中间体传递至液泡，在液泡中受体被降解。
