Machiedo G W, Brown C S, Lavigne J E, Rsuh B F
Surg Gynecol Obstet. 1976 Sep;143(3):433-6.
Twelve dogs were subjected to hemorrhagic shock by means of a modified Wiggers technique. Half were treated with prostaglandin E1, 1 microgram per kilogram per minute in 60 milliliters of saline solution, for one hour after shock, while the other half received only an equal amount of saline solution. Those dogs treated with prostaglandin E1 exhibited a significantly increased survival time and cardiac output as well as a significantly lowered total peripheral resistance when compared with those for untreated dogs. The various modes of action by which prostaglandin E1 exerts both its cardiovascular and other long term effects indicate a multisystem effect of the drug.
采用改良的维格斯技术使12只狗遭受失血性休克。其中一半在休克后1小时，以每分钟1微克/千克的剂量，在60毫升盐溶液中用前列腺素E1进行治疗，而另一半只接受等量的盐溶液。与未治疗的狗相比，用前列腺素E1治疗的狗存活时间显著延长，心输出量显著增加，总外周阻力显著降低。前列腺素E1发挥其心血管及其他长期作用的各种作用方式表明该药物具有多系统效应。
