Aikawa T, Kasahara T, Uchiyama M
Department of Pediatrics, Niigata Prefectural Kamo Hospital, Japan.
Eur Urol. 1998;33 Suppl 3:41-4. doi: 10.1159/000052242.
The aim of this group of studies was to determine the relationship between primary nocturnal enuresis and arginine-vasopressin (AVP) secretion.
The first study compared the 24-hour AVP secretion profiles of an enuretic group and a control group. Blood samples were collected every hour. In the second study, we compared nocturnal AVP secretion in group A, with low urinary osmotic pressure (UOP) and large nocturnal urinary volume (NUV), with that of group D, with normal UOP and small NUV. The plasma AVP level was measured at 30-min sampling intervals. In the third study, the change in nocturnal AVP secretion from before to after treatment was determined.
The plasma AVP level was significantly lower in the enuretic group from 23:00 through 04:00 h. The mean plasma AVP level was significantly lower in group A than in group D at all points of measurement. The mean nocturnal AVP level in group A (0.64 +/- 0.23 pg/ml) was lower than that in group D (1.43 +/- 0.72 pg/ml) (p < 0.0001). The mean nocturnal AVP level after treatment was significantly increased, from 0.47 pg/ml before treatment to 0.78 pg/ml after treatment (p = 0.01). However, a significant increase was noted in only 10 cases.
These findings suggest that decreased nocturnal AVP secretion is one of the causes of bed-wetting. However, the improvement of bed-wetting was not solely due to the increased nocturnal AVP secretion.
这组研究的目的是确定原发性夜间遗尿症与精氨酸加压素（AVP）分泌之间的关系。
第一项研究比较了遗尿组和对照组的24小时AVP分泌情况。每小时采集血样。在第二项研究中，我们比较了A组（低尿渗透压（UOP）和大量夜间尿量（NUV））与D组（正常UOP和少量NUV）的夜间AVP分泌情况。以30分钟的采样间隔测量血浆AVP水平。在第三项研究中，确定了治疗前后夜间AVP分泌的变化。
遗尿组在23:00至04:00期间血浆AVP水平显著降低。在所有测量点，A组的平均血浆AVP水平均显著低于D组。A组的平均夜间AVP水平（0.64±0.23 pg/ml）低于D组（1.43±0.72 pg/ml）（p<0.0001）。治疗后平均夜间AVP水平显著升高，从治疗前的0.47 pg/ml升至治疗后的0.78 pg/ml（p = 0.01）。然而，仅10例患者出现显著升高。
这些发现表明夜间AVP分泌减少是尿床的原因之一。然而，尿床情况的改善并非完全归因于夜间AVP分泌增加。
