Clinical and laboratory correlation of acute Henoch-Schönlein purpura in children.

The clinical and laboratory features of 72 children with Henoch-Schönlein purpura (HSP) were examined to determine if there were associations between the laboratory indices--including white blood cell (WBC) counts, serum C-reactive protein (CRP) levels, platelet (PLT) counts--and the clinical manifestations of acute HSP. Marked leukocytosis (WBC > 15,000/mm3), elevation of serum CRP levels (> 10 mg/L) and thrombocytosis (PLT > 400 x 10(3)/mm3) were associated with gastrointestinal (GI) bleeding, but not associated with abdominal pain in the absence of GI bleeding. None of the three parameters was associated with arthritis and nephritis. Elevated serum CRP levels alone was associated with prolonged hospital course, and may serve as an indicator of disease severity in patients with HSP. GI bleeding did not occur in patients with normal WBC counts, serum CRP levels, PLT counts (0/19), but occurred in 21.7% (5/23), 50% (8/16), and 85.7% (12/14) in patients with only one, two of the three and all three laboratory abnormalities, respectively. Patients with GI bleeding had higher mean WBC, PLT counts and serum CRP levels than those with abdominal pain in the absence of GI bleeding, and than those without abdominal pain. Routine measurement of these parameters is warranted to monitor children with acute HSP.