Gayret Ozlem Bostan, Erol Meltem, Tekin Nacaroglu Hikmet
Bagcilar Training and Research Hospital, Department of Pediatrics, Istanbul, Turkey.
Bagcilar Training and Research Hospital, Department of Pediatric Allergy, Istanbul, Turkey.
Iran J Pediatr. 2016 Oct 10;26(5):e8191. doi: 10.5812/ijp.8191. eCollection 2016 Oct.
Henoch-Schonlein Purpura (HSP) is the most widespread systemic vasculitis during childhood. Gastrointestinal tract retention and gastrointestinal bleeding are among its major complications. Neutrophil-Lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) are indicators related to inflammatory diseases. This study evaluated the relationship between NLR or PLR and gastrointestinal bleeding in HSP.
The study consisted of 119 patients and 40 healthy children in the same age group. White Blood Cell (WBC) count, hemoglobin level, platelet count, mean platelet volume (MPV), neutrophil count and lymphocyte count were recorded. The NLR and PLR were calculated based on the results of complete blood count tests performed during the first visit to the hospital.
The average neutrophil count and NLR of the patients with HSP were found to be significantly increased compared to the control group (P = 0.0001). No significant difference was observed between the PLR average of HSP and control groups (P = 0.053). Platelet count average (P = 0.0001) and PLR (P = 0.001) of the patients with gastrointestinal system (GIS) bleeding were found to be statistically significantly increased compared to those who did not have gastrointestinal bleeding. No significant difference was found in the NLR of the patients with and without gastrointestinal bleeding (P = 0.060).
While the NLR was significantly increased in patients with HSP in this study, the PLR was found to be more significant in patients with gastrointestinal bleeding. Similar to NLR, PLR may also be used as an inflammatory indicator among children with HSP, who have gastrointestinal bleeding.
过敏性紫癜（HSP）是儿童期最常见的系统性血管炎。胃肠道潴留和胃肠道出血是其主要并发症。中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）是与炎症性疾病相关的指标。本研究评估了NLR或PLR与HSP患者胃肠道出血之间的关系。
本研究纳入了119例患者和40名同年龄组的健康儿童。记录白细胞（WBC）计数、血红蛋白水平、血小板计数、平均血小板体积（MPV）、中性粒细胞计数和淋巴细胞计数。根据首次入院时进行的全血细胞计数测试结果计算NLR和PLR。
与对照组相比，HSP患者的平均中性粒细胞计数和NLR显著升高（P = 0.0001）。HSP组和对照组的PLR平均值之间未观察到显著差异（P = 0.053）。与无胃肠道出血的患者相比，胃肠道系统（GIS）出血患者的平均血小板计数（P = 0.0001）和PLR（P = 0.001）在统计学上显著升高。有胃肠道出血和无胃肠道出血患者的NLR无显著差异（P = 0.060）。
在本研究中，HSP患者的NLR显著升高，而PLR在胃肠道出血患者中更为显著。与NLR类似，PLR也可作为HSP合并胃肠道出血儿童的炎症指标。
