成人T细胞白血病病毒I型相关脊髓病合并多器官炎症性疾病：一例报告

HTLV-I-associated myelopathy associated with multi-organ inflammatory disease: a case report.

作者信息

Furuya T, Nakamura T, Goto H, Shirabe S, Nomata K, Kitaoka T, Kohno S, Nakamura H, Yoshimura T, Eguchi K

机构信息

The First Department of Internal Medicine, Nagasaki University School of Medicine, Japan.

出版信息

J Neurol Sci. 1998 Apr 15;157(1):109-12. doi: 10.1016/s0022-510x(98)00066-5.

DOI:10.1016/s0022-510x(98)00066-5

PMID:9600686

Abstract

We report a 73-year-old man with human T-lymphotropic virus type I (HTLV-I)-associated myelopathy (HAM) complicated with multi-organ inflammatory disease, including Sjögren's syndrome, interstitial cystitis, and uveitis. The presence of HTLV-I proviral DNA in peripheral blood mononuclear cells (PBMC), cerebrospinal fluid, salivary gland, mucosa of urinary bladder, and aqueous humor was confirmed by polymerase chain reaction using HTLV-I pX region primer. Western blot analysis revealed the presence of anti-HTLV-I antibodies in serum, CSF, saliva, and urine, suggesting replication of HTLV-I in each tissue. A high load of HTLV-I proviral DNA (20 copies out of 100 PBMC) was present, associated with increased spontaneous proliferation of peripheral blood lymphocytes (24,747 cpm). Our results suggest that the high load of HTLV-I in patients with HAM may potentially induce systemic inflammation in several organs.

摘要

我们报告了一名73岁男性，患有I型人类嗜T淋巴细胞病毒（HTLV-I）相关脊髓病（HAM），并伴有多器官炎症性疾病，包括干燥综合征、间质性膀胱炎和葡萄膜炎。通过使用HTLV-I pX区域引物的聚合酶链反应，证实外周血单核细胞（PBMC）、脑脊液、唾液腺、膀胱黏膜和房水中存在HTLV-I前病毒DNA。蛋白质印迹分析显示血清、脑脊液、唾液和尿液中存在抗HTLV-I抗体，提示HTLV-I在每个组织中复制。存在高负荷的HTLV-I前病毒DNA（每100个PBMC中有20个拷贝），与外周血淋巴细胞自发增殖增加（24,747 cpm）相关。我们的结果表明，HAM患者中高负荷的HTLV-I可能潜在地诱导多个器官的全身炎症。