Suppr超能文献

亚毫摩尔水平的钙调节二核苷酸重复序列（TG/AC）n处的DNA结构。

Submillimolar levels of calcium regulates DNA structure at the dinucleotide repeat (TG/AC)n.

作者信息

Dobi A, v Agoston D

机构信息

Molecular Control of Neurodifferentiation, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

出版信息

Proc Natl Acad Sci U S A. 1998 May 26;95(11):5981-6. doi: 10.1073/pnas.95.11.5981.

DOI:10.1073/pnas.95.11.5981
PMID:9600903
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC27571/
Abstract

Submillimolar levels of calcium, similar to the physiological total (bound + free) intranuclear concentration (0.01-1 mM), induced a conformational change within d(TG/AC)n, one of the frequent dinucleotide repeats of the mammalian genome. This change is calcium-specific, because no other tested cation induced it and it was detected as a concentration-dependent transition from B- to a non-B-DNA conformation expanding from 3' end toward the 5' of the repeat. Genomic footprinting of various rat brain regions revealed the existence of similar non-B-DNA conformation within a d(TG/AC)28 repeat of the endogenous enkephalin gene only in enkephalin-expressing caudate nucleus and not in the nonexpressing thalamus. Binding assays demonstrated that DNA could bind calcium and can compete with calmodulin for calcium.

摘要

亚毫摩尔水平的钙，类似于生理状态下细胞核内总的（结合的 + 游离的）钙浓度（0.01 - 1 mM），可诱导d(TG/AC)n发生构象变化，d(TG/AC)n是哺乳动物基因组中常见的二核苷酸重复序列之一。这种变化具有钙特异性，因为其他测试的阳离子均未诱导该变化，并且它被检测为一种浓度依赖性转变，即从B型DNA构象转变为从重复序列的3'端向5'端扩展的非B型DNA构象。对大鼠不同脑区的基因组足迹分析表明，仅在内源性脑啡肽基因的d(TG/AC)28重复序列中，在表达脑啡肽的尾状核而非不表达脑啡肽的丘脑中存在类似的非B型DNA构象。结合实验表明，DNA能够结合钙，并且可以与钙调蛋白竞争钙。

相似文献

1
Submillimolar levels of calcium regulates DNA structure at the dinucleotide repeat (TG/AC)n.
Proc Natl Acad Sci U S A. 1998 May 26;95(11):5981-6. doi: 10.1073/pnas.95.11.5981.
2
Isolation and structural and genetic analysis of the mouse enkephalin gene and its d(AC/TG)n repeats.
DNA Seq. 1998;9(4):217-26. doi: 10.3109/10425179809105208.
3
A novel rat genomic simple repeat DNA with RNA-homology shows triplex (H-DNA)-like structure and tissue-specific RNA expression.
Biochem Biophys Res Commun. 2005 Feb 4;327(1):276-86. doi: 10.1016/j.bbrc.2004.12.015.
4
Perturbations in DNA structure upon interaction with porphyrins revealed by chemical probes, DNA footprinting and molecular modelling.
Bioorg Med Chem. 1995 Jun;3(6):671-7. doi: 10.1016/0968-0896(95)00052-i.
5
Topoisomerase II-mediated DNA cleavage on the cruciform structure formed within the 5'upstream region of the human beta-globin gene.
Mol Cells. 1998 Aug 31;8(4):424-30.
6
The non-B-DNA structure of d(CA/TG)n does not differ from that of Z-DNA.
Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9549-53. doi: 10.1073/pnas.91.20.9549.
7
Sequence preference for BI/BII conformations in DNA: MD and crystal structure data analysis.
J Biomol Struct Dyn. 2005 Aug;23(1):13-27. doi: 10.1080/07391102.2005.10507043.
8
Interaction in vitro of type III intermediate filament proteins with Z-DNA and B-Z-DNA junctions.
DNA Cell Biol. 2003 Mar;22(3):141-69. doi: 10.1089/104454903321655783.
9
A terbenzimidazole that preferentially binds and conformationally alters structurally distinct DNA duplex domains: a potential mechanism for topoisomerase I poisoning.
Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13565-70. doi: 10.1073/pnas.94.25.13565.
10
The non-B-DNA structure of d(CA/TG)n differs from that of Z-DNA.
Proc Natl Acad Sci U S A. 1994 Mar 1;91(5):1898-902. doi: 10.1073/pnas.91.5.1898.

引用本文的文献

1
The unusual structural properties and potential biological relevance of switchback DNA.
Nat Commun. 2024 Aug 6;15(1):6636. doi: 10.1038/s41467-024-50348-3.
2
The unusual structural properties and potential biological relevance of switchback DNA.
bioRxiv. 2024 Apr 12:2023.11.15.563609. doi: 10.1101/2023.11.15.563609.
3
Physiology of intracellular calcium buffering.
Physiol Rev. 2023 Oct 1;103(4):2767-2845. doi: 10.1152/physrev.00042.2022. Epub 2023 Jun 16.
4
Interplay between biofilm microenvironment and pathogenicity of in cystic fibrosis lung chronic infection.
Biofilm. 2022 Oct 22;4:100089. doi: 10.1016/j.bioflm.2022.100089. eCollection 2022 Dec.
5
The Role of Lamins in the Nucleoplasmic Reticulum, a Pleiomorphic Organelle That Enhances Nucleo-Cytoplasmic Interplay.
Front Cell Dev Biol. 2022 Jun 16;10:914286. doi: 10.3389/fcell.2022.914286. eCollection 2022.
6
Inositol 1, 4, 5-trisphosphate-dependent nuclear calcium signals regulate angiogenesis and cell motility in triple negative breast cancer.
PLoS One. 2017 Apr 4;12(4):e0175041. doi: 10.1371/journal.pone.0175041. eCollection 2017.
7
Regulation of gene expression by NFAT transcription factors in hibernating ground squirrels is dependent on the cellular environment.
Cell Stress Chaperones. 2016 Sep;21(5):883-94. doi: 10.1007/s12192-016-0713-5. Epub 2016 Jun 25.
8
Quantitative imaging of magnesium distribution at single-cell resolution in brain tumors and infiltrating tumor cells with secondary ion mass spectrometry (SIMS).
J Neurooncol. 2016 Mar;127(1):33-41. doi: 10.1007/s11060-015-2022-8. Epub 2015 Dec 24.
9
Probing solid-state nanopores with light for the detection of unlabeled analytes.
ACS Nano. 2014 Nov 25;8(11):11836-45. doi: 10.1021/nn505545h. Epub 2014 Nov 5.
10
Great insight created by tiny holes; celebrating 40 years of brain micropunch technique.
Front Neuroanat. 2014 Jul 11;8:61. doi: 10.3389/fnana.2014.00061. eCollection 2014.

本文引用的文献

1
Identification of processes that influence negative supercoiling in the human c-myc gene.
Biochim Biophys Acta. 1997 May 30;1352(2):213-21. doi: 10.1016/s0167-4781(97)00015-8.
2
Detection of conformation bias between the complementary strands of deoxynucleotide repeat (TG/AC)n.
Electrophoresis. 1997 Jan;18(1):12-6. doi: 10.1002/elps.1150180104.
3
A nuclear traffic jam - unraveling multicomponent machines and compartments.
Curr Opin Cell Biol. 1996 Jun 1;8(3):299-302.
4
Hyper-negative template DNA supercoiling during transcription of the tetracycline-resistance gene in topA mutants is largely constrained in vivo.
Nucleic Acids Res. 1996 Aug 1;24(15):3093-9. doi: 10.1093/nar/24.15.3093.
5
The biology of left-handed Z-DNA.
J Biol Chem. 1996 May 17;271(20):11595-8. doi: 10.1074/jbc.271.20.11595.
6
Intercalation, DNA kinking, and the control of transcription.
Science. 1996 Feb 9;271(5250):778-84. doi: 10.1126/science.271.5250.778.
7
The elemental principles of calcium signaling.
Cell. 1995 Dec 1;83(5):675-8. doi: 10.1016/0092-8674(95)90179-5.
8
Z-DNA binding protein from chicken blood nuclei.
Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3339-42. doi: 10.1073/pnas.90.8.3339.
9
m-Calpain requires DNA for activity on nuclear proteins at low calcium concentrations.
J Biol Chem. 1993 Jan 5;268(1):653-7.
10
B-DNA to Z-DNA structural transitions in the SV40 enhancer: stabilization of Z-DNA in negatively supercoiled DNA minicircles.
Biochemistry. 1993 Mar 9;32(9):2167-76. doi: 10.1021/bi00060a007.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验