一种人痘病毒趋化因子同源物的广谱趋化因子拮抗活性
Broad spectrum chemokine antagonistic activity of a human poxvirus chemokine homolog.
作者信息
Damon I, Murphy P M, Moss B
机构信息
Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Proc Natl Acad Sci U S A. 1998 May 26;95(11):6403-7. doi: 10.1073/pnas.95.11.6403.
Abstract
A secreted CC chemokine homolog, encoded by the MC148 gene of molluscum contagiosum virus, potently interfered with the chemotaxis of human monocytes, lymphocytes, and neutrophils in response to a large number of CC and CXC chemokines with diverse receptor specificities. Evidence that the viral protein binds to human chemokine receptors was obtained by competition binding and calcium mobilization experiments. The broad spectrum chemokine antagonistic activity of MC148 can explain the prolonged absence of an inflammatory response in skin tumors that harbor replicating molluscum contagiosum virus.
摘要
一种由传染性软疣病毒的MC148基因编码的分泌型CC趋化因子同源物，能有效干扰人类单核细胞、淋巴细胞和中性粒细胞对多种具有不同受体特异性的CC和CXC趋化因子的趋化作用。通过竞争结合和钙动员实验获得了该病毒蛋白与人趋化因子受体结合的证据。MC148广泛的趋化因子拮抗活性可以解释携带正在复制的传染性软疣病毒的皮肤肿瘤中炎症反应长期缺失的现象。
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