Dale D C
Department of Medicine, University of Washington 98195-6422.
Trans Am Clin Climatol Assoc. 1998;109:27-36; discussion 36-8.
The story of the discovery, development and applications of G-CSF illustrates many of the best features of modern laboratory and clinical investigation. The initial discovery of the CSFs was somewhat serendipitous. The pathway to understanding the cellular and molecular base for the action of these substances was long, but fruitful and exciting for those who pursued it tirelessly. The power of modern molecular biology is illustrated by the rapid advances which followed the cloning of the G-CSF gene. Major advances in our understanding of the regulation of neutrophil production and deployment have followed, together with many important clinical observations. To date hundreds of thousands of patients have been treated with G-CSF and some individuals with severe chronic neutropenia have received daily therapy for more than ten years. Results of recent studies suggest that there will be many more interesting and important clinical applications for G-CSF.
粒细胞集落刺激因子（G-CSF）的发现、研发及应用历程展现了现代实验室研究与临床研究的诸多卓越特性。集落刺激因子（CSF）的最初发现颇具偶然性。探寻这些物质作用的细胞与分子基础之路漫长，但对于那些不懈探索的人而言，成果丰硕且令人振奋。G-CSF基因克隆后取得的快速进展彰显了现代分子生物学的强大力量。随之而来的是我们对中性粒细胞生成与调控理解上的重大进展，以及诸多重要的临床观察结果。迄今为止，已有数十万患者接受了G-CSF治疗，一些严重慢性中性粒细胞减少症患者已接受了长达十多年的每日治疗。近期研究结果表明，G-CSF将会有更多有趣且重要的临床应用。
