Wiest G H, Ficker J H, Lehnert G, Hahn E G
Abteilung Pneumologie, Medizinischen Klinik I mit Poliklinik, Friedrich-Alexander-Universität, Erlangen-Nürnberg.
Dtsch Med Wochenschr. 1998 Apr 24;123(17):522-6. doi: 10.1055/s-2007-1024005.
A 67-year-old woman complained of marked daytime sleepiness, as well as loud snoring and apnoeas during sleep. She was known to have had 3 thyroidectomies for goitre 41, 23 and 12 years ago, with known tracheal stenosis and recurrent nerve palsy for 11 years. Physical examination revealed marked stridor, hoarse voice and slightly enlarged and palpable recurrent right thyroid.
Polysomnography demonstrated a clearly elevated obstructive sleep apnoea activity (apnoea index: 34/h, apnoea-hypopnea index: 40/h, desaturation index: 31/h, minimal saturation: 63%). Selective tracheal imaging showed subglottic tracheal stenosis with an inspiratory luminal diameter of 4 mm and an expiratory luminal diameter of 8 mm. Lung function analysis revealed marked flattening of the flow-volume curve as sign of a functionally effective tracheal stenosis. These findings indicated a secondary obstructive sleep apnoea (OSA) due to tracheal stenosis and bilateral recurrent nerve palsy. The patient declined further studies, such as bronchoscopy.
As the patient did not want any surgical treatment, nasal continuous positive airway pressure therapy (CPAP) was instituted as a trial. No apnoea occurred at a pressure of 12 mm H2O and this was well tolerated. She has now continued CPAP at home for 12 months and her vigilance was markedly improved.
Tracheal stenosis or recurrent nerve palsy is a rare cause of OSA which can be effectively treated by nasal CPAP.
一名67岁女性主诉白天极度嗜睡,睡眠时伴有大声打鼾及呼吸暂停。据悉,她曾于41、23和12年前因甲状腺肿接受过3次甲状腺切除术,已知存在气管狭窄和喉返神经麻痹11年。体格检查发现明显的喘鸣、声音嘶哑,右侧甲状腺再次肿大且可触及。
多导睡眠监测显示阻塞性睡眠呼吸暂停活动明显升高(呼吸暂停指数:34次/小时,呼吸暂停低通气指数:40次/小时,血氧饱和度下降指数:31次/小时,最低血氧饱和度:63%)。选择性气管成像显示声门下气管狭窄,吸气时管腔直径为4毫米,呼气时管腔直径为8毫米。肺功能分析显示流量-容积曲线明显变平,提示存在功能性有效的气管狭窄。这些发现表明因气管狭窄和双侧喉返神经麻痹导致继发性阻塞性睡眠呼吸暂停(OSA)。患者拒绝进一步检查,如支气管镜检查。
由于患者不希望接受任何手术治疗,遂试行鼻持续气道正压通气治疗(CPAP)。在12毫米水柱的压力下未出现呼吸暂停,且耐受性良好。她现已在家中持续使用CPAP 12个月,警觉性明显改善。
气管狭窄或喉返神经麻痹是OSA的罕见病因,可通过鼻CPAP有效治疗。