Tortosa A, Blanco R, Ferrer I
Departament d'Infermeria Médico-Quirúrgica, Universitat de Barcelona,Spain.
Neuroreport. 1998 Apr 20;9(6):1049-52. doi: 10.1097/00001756-199804200-00017.
Double-labeling immunohistochemistry to Bcl-2 and Bax and to tau protein was examined in the brains of patients with progressive supranuclear palsy (PSP) to study the possible relationship between the expression of Bax and Bcl-2 proteins and neurofibrillary tangle formation. No differences between Bcl-2 and Bax immunoreactivity in neurons of the brain stem were observed in PSP patients and controls. Moreover, the intensity of Bcl-2 and Bax immunoreactivity was similar in tangle-bearing and non-tangle-bearing neurons in PSP patients. These results suggest that Bcl-2 and Bax are probably not implicated in neurofibrillary tangle formation in PSP.
