Nishimura T, Ikeda K, Akiyama H, Kondo H, Kato M, Li F, Iseki E, Kosaka K
Department of Psychiatry, Yokohama City University School of Medicine, Japan.
Neurosci Lett. 1995 Dec 8;201(2):123-6. doi: 10.1016/0304-3940(95)12151-x.
We have investigated tau-positive structures immunohistochemically in the cerebral cortex of patients with progressive supranuclear palsy (PSP). In addition to neurofibrillary tangles, a variety of tau-positive structures occur. They are particularly abundant in the precentral gyrus and other frontal cortices. Double immunostaining has demonstrated that coil-like structures (coiled bodies) are located in the oligodendroglial cell bodies. Three forms of tau-positive astrocytic inclusions are discerned: those with tuft-like profiles, thorn-like structures, and concentric clusters of short stubby fibers. The concentric clusters of tau-positive fibers are present in some, but not all, PSP brains. They appear to be identical to 'astrocytic plaques' previously reported in patients with corticobasal degeneration (CBD). PSP and CBD might share a common pathological background which causes abnormal accumulation of tau protein in neurons and glial cells of neuroectodermal origin.
我们运用免疫组织化学方法对进行性核上性麻痹（PSP）患者大脑皮质中的tau蛋白阳性结构进行了研究。除神经原纤维缠结外，还出现了多种tau蛋白阳性结构。它们在中央前回和其他额叶皮质中尤为丰富。双重免疫染色显示，线圈样结构（卷曲小体）位于少突胶质细胞体中。可识别出三种形式的tau蛋白阳性星形胶质细胞包涵体：具有簇状形态的、棘状结构的以及短粗纤维同心簇状的。tau蛋白阳性纤维的同心簇状结构存在于部分但并非所有的PSP患者大脑中。它们似乎与先前在皮质基底节变性（CBD）患者中报道的“星形胶质斑块”相同。PSP和CBD可能具有共同的病理背景，该背景导致tau蛋白在神经外胚层起源的神经元和胶质细胞中异常蓄积。
