Fisher K, Coderre T J
Pain Mechanisms Laboratory, Clinical Research Institute of Montreal, Quebec, Canada.
Neuroreport. 1998 Apr 20;9(6):1169-72. doi: 10.1097/00001756-199804200-00038.
To investigate the role of Group I mGluRs in allodynia and hyperalgesia, we examined the behavioural responses of rats to noxious and non-noxious mechanical and thermal stimuli following intrathecal (i.t.) treatment (25 nmol) with the selective mGluR1/5 agonist, (RS)-dihydroxyphenylglycine ((RS)-DHPG). (RS)-DHPG administration produced a persistent decrease in response latency on a 48 degrees C hotplate, a reduction in the 50% response threshold to von Frey hairs, and an increase in responses to a tail pinch. These data suggest that activation of spinal mGluR1/5 receptors plays a role in the development of persistent allodynia and hyperalgesia associated with tissue or nerve injury.
为了研究I组代谢型谷氨酸受体（mGluRs）在痛觉过敏和异常性疼痛中的作用，我们检测了鞘内注射（i.t.）25 nmol选择性mGluR1/5激动剂（RS）-二羟基苯甘氨酸（（RS）-DHPG）后大鼠对伤害性和非伤害性机械及热刺激的行为反应。给予（RS）-DHPG后，48℃热板上的反应潜伏期持续缩短，对von Frey毛的50%反应阈值降低，对夹尾刺激的反应增加。这些数据表明，脊髓mGluR1/5受体的激活在与组织或神经损伤相关的持续性痛觉过敏和异常性疼痛的发展中起作用。
