Huskić J, Kulenović H
Institut za fiziologiju i biohemiju, Medicinski fakultet, Sarajevo.
Med Arh. 1996;50(3-4):77-80.
The serum angiotensin converting enzyme (ACE) in 30 patients with untreated essential arterial hypertension, 30 patients with chronic renal failure accompanied with arterial hypertension and 30 healthy individuals was measured. The subjects of both sexes have been old 35-60 years. The serum ACE activity was determined by the spectrophotometric method, using Hip-Gly-Gly as a substrate. The serum ACE activity significantly increased in patients with arterial hypertension (32.48 +/- 2.02; X +/- SEM) and patients with chronical renal failure accompanied with arterial hypertension (37.10 +/- 1.45) when compared to the healthy individuals (20.83 +/- 1.33). Possible mechanisms of increasing ACE activity with the patients suffering of arterial hypertension are discussed.
对30例未经治疗的原发性动脉高血压患者、30例伴有动脉高血压的慢性肾衰竭患者和30名健康个体的血清血管紧张素转换酶（ACE）进行了检测。受试者均为35至60岁的男女。采用分光光度法，以Hip-Gly-Gly为底物测定血清ACE活性。与健康个体（20.83±1.33）相比，动脉高血压患者（32.48±2.02；X±SEM）和伴有动脉高血压的慢性肾衰竭患者（37.10±1.45）的血清ACE活性显著升高。文中讨论了动脉高血压患者ACE活性增加的可能机制。
