Pompei P, Angeletti S, Ciccocioppo R, Colombo G, Gessa G L, Massi M
Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, Via Scalzino 3, 62032 Camerino, Italy.
Brain Res Mol Brain Res. 1998 May;56(1-2):277-80. doi: 10.1016/s0169-328x(98)00043-6.
Increasing evidence suggests that TKergic mechanisms might play a role in ethanol intake control. Preprotachykinin-A (PPT-A) mRNA brain levels were measured in Sardinian alcohol-preferring (sP) and Sardinian alcohol-nonpreferring (sNP) rats. PPT-A mRNAs were about 50% lower in sP than in sNP rats in the bed nucleus of the stria terminalis (BNST), whereas levels in the olfactory tubercle (Tu) were about 30% higher in sP than in sNP rats. Our findings suggest that altered PPT-A gene expression might contribute to the different ethanol preference and intake of sP opposite to sNP rats.
越来越多的证据表明，速激肽能机制可能在乙醇摄入控制中发挥作用。在撒丁岛嗜酒（sP）和撒丁岛不嗜酒（sNP）大鼠中测量了前速激肽原A（PPT-A）mRNA的脑水平。在终纹床核（BNST）中，sP大鼠的PPT-A mRNA水平比sNP大鼠低约50%，而在嗅结节（Tu）中，sP大鼠的水平比sNP大鼠高约30%。我们的研究结果表明，PPT-A基因表达的改变可能导致sP大鼠与sNP大鼠在乙醇偏好和摄入量上的差异。
