Phornphutkul C, Boney C M, Gruppuso P A
Department of Pediatrics, Rhode Island Hospital, Providence 02903, USA.
J Pediatr. 1998 May;132(5):882-4. doi: 10.1016/s0022-3476(98)70325-7.
A 16-year-old boy with insulin-dependent diabetes mellitus (IDDM) and a history of marginal glycemic control had severe hypoglycemia unawareness and a marked decrease in insulin requirement. His counterregulatory hormone response at the time of hypoglycemia suggested adrenocortical and adrenomedullary dysfunction. Further testing confirmed Addison disease. The patient's hypoglycemia unawareness was reversed by glucocorticoid replacement, although the plasma epinephrine response to hypoglycemia remained undetectable.
一名16岁的胰岛素依赖型糖尿病（IDDM）男孩，既往血糖控制不佳，出现严重低血糖无知觉且胰岛素需求量显著减少。他在低血糖时的反调节激素反应提示肾上腺皮质和肾上腺髓质功能障碍。进一步检查确诊为艾迪生病。尽管低血糖时血浆肾上腺素反应仍无法检测到，但糖皮质激素替代治疗使患者的低血糖无知觉得到了纠正。
