Serra A, Estrach M T, Martí R, Villamor N, Rafel M, Montserrat E
Department of Hematology, Hospital Clínic de Barcelona, Universitat de Lleida, Spain.
Acta Derm Venereol. 1998 May;78(3):198-200. doi: 10.1080/000155598441521.
Mature T-cell malignancies of extracutaneous origin are rare disorders. T-cell prolymphocytic leukaemia (T-PLL) is the most common form of all mature T-cell leukaemias in adults. Secondary skill involvement by T-PLL has been reported in 25% of patients. A case of T-PLL which presented with cutaneous infiltration mimicking a cellulitis-like lesion resistant to antibiotic therapy is described. The diagnosis of T-PLL was subsequently fully supported by the clinical, laboratory and cytological findings, as well as by the immunophenotypic study of the skin biopsy. The present case stresses the importance of accurate evaluation of skin lesions in the diagnosis of some haematological conditions and gives additional information about T-PLL such as a previously non-reported cytogenetic abnormality [t(6;6)] and lack of cutaneous lymphocytic-associated antigen expression.
皮肤外起源的成熟T细胞恶性肿瘤是罕见疾病。T细胞原淋巴细胞白血病（T-PLL）是成人所有成熟T细胞白血病中最常见的形式。据报道，25%的患者会出现T-PLL继发脾脏受累。本文描述了一例T-PLL病例，该病例表现为皮肤浸润，类似对抗生素治疗耐药的蜂窝织炎样病变。随后，临床、实验室和细胞学检查结果以及皮肤活检的免疫表型研究充分支持了T-PLL的诊断。本病例强调了在某些血液系统疾病诊断中准确评估皮肤病变的重要性，并提供了有关T-PLL的更多信息，如先前未报道的细胞遗传学异常[t(6;6)]以及皮肤淋巴细胞相关抗原表达缺失。
