字里行间的解读：主要组织相容性复合体I类分子所呈递的天然加工肽段

Reading within the lines: naturally processed peptides displayed by MHC class I molecules.

作者信息

Shastri N, Serwold T, Paz P

机构信息

Department of Molecular and Cell Biology, University of California, Berkeley 94720-3200, USA.

出版信息

Curr Opin Immunol. 1998 Apr;10(2):137-44. doi: 10.1016/s0952-7915(98)80241-0.

DOI:10.1016/s0952-7915(98)80241-0

PMID:9602301

Abstract

A typical mammalian cell contains tens of thousands of different gene products. Snippets of this genetic information are displayed on the cell surface by MHC class I molecules as short peptides for immune surveillance by CD8+ T lymphocytes. Genetic and biochemical analysis of these peptides is revealing novel sources and mechanisms by which these peptide/MHC class I complexes arise.

摘要

一个典型的哺乳动物细胞含有成千上万种不同的基因产物。这些遗传信息的片段以短肽的形式由MHC I类分子呈递在细胞表面，以供CD8 + T淋巴细胞进行免疫监视。对这些肽的遗传学和生物化学分析正在揭示这些肽/MHC I类复合物产生的新来源和机制。